Estudo dos efeitos cardiovasculares do óleo essencial Lippia sidoides em ratos normotensos

• Ano de defesa: 2022
• Autor(a) principal: Caminha, Édipo Luan de Carvalho
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Óleos Voláteis; Sistema Cardiovascular; Pressão Arterial; Lippia
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/70019

The use of products of natural origin has been widespread and researched as an aid in the fight against some conditions. This therapeutic use comes from ancient practices in the prevention and cure of diseases worldwide. Lippia sidoides essential oil (OELS) is a substance derived from rosemary-pepper, a plant that belongs to the Verbenaceae family, well present in the northeast region of Brazil, has several compounds, in greater abundance thymol and carvacrol, which have shown several effects on the nervous system and fight inflammation, in this sense the OELS is a compound that has great potential for application in the cardiovascular area, especially as a therapeutic agent in the treatment of vasoconstriction caused by several hypertensive mechanisms. The purpose of the study was to study the cardiovascular effects of lippia sidoides essential oil in normotensive rats. Normotensive Wistar rats were used, each series of experiments was performed on 6 to 8 animals per group, and on 5 to 6 isolated tissue segments. Animals were anesthetized and experiments were performed with intact vagus nerve and after bivagotomy, experiments were performed with isolated aortic tissues. The study showed that OELS induced rapid hypotension and significant bradycardia in anesthetized rats with and without an intact vagus nerve and with perineural treatment. It was possible to identify three moments called P1, which is a phase resulting from a probable vagus nerve reflex, and phase P2, which was the effect of the OELS. Studies suggest that the essential oil lippia sidoides can exert its action, even with neural inhibition by vagotomy and perineural treatment, and that the P2 period is the result of its cardiovascular response. It is concluded that the essential oil lippia sidoides was able to reduce blood pressure in these animals, further studies are suggested to analyze it in the presence of other pharmacological agents for investigations of more cardiovascular effects.