Avaliação da hipertermoterapia associada ao Paclitaxel, 5-Fluorouracil e 5-Fluorouracil mais Ácido Folínico no Tumor de Walker 256 implantado em estômagos de rato

• Ano de defesa: 2003
• Autor(a) principal: Oliveira, Paulo Ferdinando de Melo
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Febre; Quimioterapia; Neoplasias Gástricas
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/3737

The conventional chemotherapy drugs have not obtained success on the treatment of gastric cancer. The paclitaxel (Taxol®) showed to be effective on treating lung, breast and ovarian cancer. The 5-fluorouracil (5-FU) has shown promising results on the treatment of colon cancer. The folinic acid (Leucovorin®) reinforces the 5-FU cytotoxicity. Studies developed in Japan, United States and Europe suggest the use of chemotherapy associated with hyperthermia on the control of locally advanced disease. Objectives: Evaluate the influence of paclitaxel, 5-fluorouracil and 5-fluorouracil plus folinic acid, isolated and associated with hyperthermia, on the survival of rats with Walker 256 tumor implanted on their stomach, and observe the behavior of the original Walker 256 tumor implanted in the stomach of rats with no treatment and with the proposed chemotherapy treatments associated with hyperthermia. Methods: The Walker 256 tu-mor was implanted on the mucous layer of the rat stomach on the 3rd, 7th and 10th day after inoculation. The animals were treated with paclitaxel, 5-fluorouracil and 5-fluorourcil plus folinic acid isolated and associated with hyperthermia. Paclitaxel 25 mg/m2, 5-fluorouracil 130 mg/m2 and folinic acid 7 mg/m2 were used. The Whole-Body Hyperthermia was initiated 2 hours after the administration of the chemotherapic drugs, with 1 hour of duration. Results: The animals in-oculated with tumor showed a survival of 13.25 ± 0.53. The animals treated with Paclitaxel isolated showed a survival of 28.61 ± 0.82; 20.92 ± 1.77 and 20.07 ± 0.60 in the 3rd, 7th and 10th days, respectively, and those treated with Paclitaxel + hyperthermia showed a survival of 19.17 ± 1.20; 22.54 ± 1.47 and 17.92 ± 1.06 in the same periods. The animals treated with 5-fluorouracil isolated showed a survival of 16.16 ± 0.52; 15.57 ± 0.57 and 17.94 ± 0.46 in the 3rd, 7th and 10th days, respectively, and those treated with 5-fluorouracil + hyperthermia showed a survival of 14.45 ± 0.36; 16.36 ± 0.81 and 18.37 ± 1.86 in the same periods. The animals treated with 5-fluorouracil + folinic acid showed a survival of 14.89 ± 0.71; 16.56 ± 0.91 and 16.11 ± 0.67 in the 3rd, 7th and 10th days, respectively, and those treated with 5-fluorouracil + folinic acid + hyperthermia showed a survival of 17.60 ± 1.22; 15.42 ± 0.31 and 15.45 ± 0.39 in the same periods. Conclusions: The Walker 256 is a small cell tumor. The hyperthermia associated with chemotherapy using pacli-taxel, 5-fluorouracil and 5-fluorouracil plus folinic acid as treatment of Walker experimental tu-mor implanted in Wistar rat stomachs do not improved the survival.