Função de barreira do epitélio intestinal e fatores de risco cardiovascular em indivíduos com excesso de peso com ou sem síndrome metabólica

• Ano de defesa: 2023
• Autor(a) principal: Bona, Mariana Duarte
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Síndrome Metabólica; Fatores de Risco de Doenças Cardíacas; Mucosa Intestinal
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/72409

Intestinal epithelial barrier dysfunction in the face of systemic inflammatory state observed in conditions of overweight/obesity or associated metabolic syndrome is well discussed in animal models. However, there is a lack of studies that evaluate this thematic in humans. This study aimed to verify if there was alteration of the intestinal epithelial barrier function (IEBF) due overweight/obesity, the metabolic syndrome and the risk factors for cardiovascular diseases. A case-control study was carried out from September 2019 to July 2022 with adults and elderly people in Natal-RN. Socio-demographic data, anthropometric assessment data, and urine and blood samples were collected. Anthropometric, biochemical and inflammatory assessment estimated cardiovascular risk factors. IEBF was performed by lactulose:mannitol test using urine samples analyzed by High Pressure Liquid Chromatography (HPLC-PAD). Correlations between IEBF, anthropometric and metabolic parameters were evaluated using Spearman’s correlations (ρ). In overall, 92 individuals participated in the study, where 34 were controls, 30 were overweight/obese without metabolic syndrome and 28 were overweight/obese with metabolic syndrome. It was observed that individuals with metabolic syndrome had increased some cardiovascular risk factors, but did not alter IEBF. The urinary excretion of lactulose/mannitol ratio was similar between the groups (p = 0.473). In the group of overweight/obese people without metabolic syndrome, there were significant positive correlations between mannitol excretion and diastolic pressure (ρ = 0,394, p = 0,031), waist circumference (ρ = 0,429, p = 0,018) and visceral adiposity index (ρ = 0,423, p = 0,02). In the overweight/obesity with metabolic syndrome group, there were significantly positive correlations between lactulose excretion and waist circumference (ρ = 0,397, p = 0,037), between mannitol excretion and Very Low Density Lipoprotein (VLDL) (ρ = 0,381, p = 0,045) and between lactulose/mannitol ratio and weight (ρ = 0,503, p = 0,006) and waist circumference (ρ = 0,447, p = 0,017). The data showed that was no change in IEBF associated with overweight/obesity or the metabolic syndrome compared to controls. However, cardiovascular risk variables were correlated with IEBF parameters in overweight/obesity with or without metabolic syndrome suggesting that the increased cardiovascular risk factors were associated with alteration of IEBF parameters.