Efeitos comportamentais do uso prolongado de levodopa em pacientes com doença de Parkinson

• Ano de defesa: 2016
• Autor(a) principal: Rosal, Veronesia Maria de Sena
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Doença de Parkinson; Comportamento Compulsivo; Levodopa
• Link de acesso: http://www.repositorio.ufc.br/handle/riufc/21323

Parkinson's disease (PD) is clinically defined by motor signals. However, non-motor symptoms are frequent and, sometimes, more incapacitating than the motor, which are poorly recognized and thus inadequately treated, worsening the quality of life of the patient, besides increasing the poor prognosis. The gold standard treatment of the disease is the use of levodopa, the precursor drug of dopamine, the main neurotransmitter related to motor phenomena. However, its prolonged use is associated with several side effects and complications, being a source of functional incapacitation of the most important, rivaling the motor findings, where impulsive and compulsive disorders gain more and more prominence. Far beyond motor issues, the non-motor phenomena of the disease call attention not only to the incapacities associated with them, but also to the fact that the available therapy can aggravate and increase the severity of this condition. The aim of this study is to identify and describe symptoms associated with impulse control disorders and other compulsive behaviors in patients with Parkinson's disease in prolonged use of levodopa. For this purpose, structured interviews were performed with the application of validated instruments and scales to verify behavioral changes that meet the diagnostic criteria established for PD. The severity of the disease was assessed using the UPDRS and Schwab & England scales. The cognitive assessment was based on the SCOPA scale. To evaluate the control of impulses and compulsions, the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease (QUIP C) was applied. We evaluated 43 patients, mean age 62.9 and disease time 10.3 years. In conclusion, it was evidenced the presence of disorders of impulse control and other compulsive behaviors, being identified episodes of pathological gambling, excessive purchase and alteration in the dietary pattern. Reports of SDD, punding, hobby, walkabout, hypersexuality and zoophilia were observed, the latter with prevalence above that described in other studies. The findings confirm literature data indicating that in addition to factors such as age and sex, others such as pharmacological treatment and the actual process of treating the disease may be related due to disruption or disruption of inhibitory functions, particularly by the prolonged use of levodopa .