Produtos utilizados no controle do mosquito Aedes aegypti (Diptera:Culicidae)

• Ano de defesa: 2007
• Autor(a) principal: Ribeiro Júnior, Karlos Antônio Lisboa
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Federal de Alagoas; BR; Química; Biotecnologia; Programa de Pós-Graduação em Química e Biotecnologia; UFAL
• Palavras-chave em Português: Aedes aegypti; Controle vetorial; Dengue; Produtos naturais; Vector; Natural product; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: http://repositorio.ufal.br/handle/riufal/1088

In face of the increasingly difficult control of mosquitoes with synthetic chemical insecticides due to the appearance of resistance and their toxicity to mammals, the search for new phytocompounds has been emphasized as it is believed that they may offer a larger selectivity to mosquitoes with lower toxicity and larger biodegrability, besides being largely available in nature. Thus, the objective of this work was to evaluate the larvicidal activity of several natural compounds. The methodology used in the larvicidal bioassays followed WHO s recommendations. The initial bioassays were carried out with 25 4th-instar Aedes aegypti larvae in four repetitions in 250-mL disposable plastic cups with 25 mL of solution. The larvae were considered dead if they could not reach the surface of the solution when the recipient was agitated. In consonance with the objective of the LPqRN of developing a larvicidal for the control of A. aegypti, we evaluated the plants extracts, synthetic and isolated compounds from plants in the search of a potential larvicidal for use in the control of the mosquito in its larval phase. In the first chapter, it is described the activity of four diterpenes isolated from Xylopia langsdorffiana St-Hil & Tul. The acids ent-7-α-acetoxytrachiloban-18-oic and ent-7-α-Hidroxytrachiloban-18-oic stood out, demonstrating high larvicidal potential and lethal concentrations comparable to that of rotenone, a well-known vegetable insecticide.The second chapter describes the evaluation of the larvicidal activity of eleven quinones. They represent an excellent alternative for the control of Aedes aegypti. Compound 3-bromo-5-hydroxy-1,4-naphthoquinone stood out among the quinones tested for its low lethal concentration. The third chapter reports on the evaluation of the activity of the ethanolic extracts obtained from the leaves, stem, roots, twigs, and tubers of Turbina cordata. Despite the low activity values of the leaf and stem ethanol extracts comparatively to those of other extracts of the plants of the same family, they still are outstanding. Furthermore, the fourth chapter reports on the larvicidal activity of terpenoids and phenylpropanoids, compounds commonly found in several essential oils. Limonene stood out among the substances evaluated. These results point to the potential of some of the compounds evaluated as natural larvicidals