Avaliação de reações adversas a medicamentos utilizados em pacientes com doenças crônicas no Hospital Universitário Regional de Maringá

• Ano de defesa: 2013
• Autor(a) principal: Gaeti-Franco, Walderez Penteado
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Estadual de Maringá; Brasil; Programa de Pós-Graduação em Ciências da Saúde; UEM; Maringá, PR; Centro de Ciências da Saúde
• Palavras-chave em Português: Reações adversas a medicamentos; Interações medicamentosas; Levotiroxina; Femprocumona; Anticonvulsivantes; Antígenos HLA; Síndrome DRESS; Brasil.; Anticonvulsant drugs; Adverse drug reactions; DRESS syndrome; HLA Antigens; Brazil.; Ciências da Saúde; Medicina
• Link de acesso: http://repositorio.uem.br:8080/jspui/handle/1/2020

In this work we report two cases of DRESS syndrome associated with the use of carbamazepine and phenytoin in white Brazilian boys who were tested for HLA class I and II alleles. The clinical manifestations were similar: a maculopapular eruption progressing to exfoliative erythroderma, fever, and lymphadenopathy. Leukocytosis, atypical lymphocytes and liver injury were also observed. Assessment of causality using the Naranjo algorithm established in these cases a possible (score 6) relationship. Human leukocyte class I antigen (HLA Class I) genes have been identified as predictors for certain severe cutaneous adverse drug reaction syndromes, although HLA alleles and drug hypersensitivity is drug, disease phenotype, and ethnicity specific. Nonetheless, none of the reported cases presented either HLA-B-0801-TNF2-DRB1*03-DQB1*02 or HLA-A*3101.