Detalhes bibliográficos
| Ano de defesa: |
2019 |
| Autor(a) principal: |
Santos, Daniela dos |
| Orientador(a): |
Bonini, Juliana Sartori
 |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Dissertação
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| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Universidade Estadual do Centro-Oeste
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| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Ciências Farmacêuticas (Mestrado / Associação Ampla com UEPG)
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| Departamento: |
Unicentro::Departamento de Farmácia
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| País: |
Brasil
|
| Palavras-chave em Português: |
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| Palavras-chave em Inglês: |
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| Área do conhecimento CNPq: |
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| Link de acesso: |
http://tede.unicentro.br:8080/jspui/handle/jspui/1747
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Resumo: |
Introduction: Aging is a natural process in which biological changes favoring the onset of dementia; which are characterized as syndromes that impair memory, thinking, behavior and alteration of daily activities. Alzheimer's disease (AD) is characterized as a disease of progressive, degenerative and irreversible damage that affects areas of the cortex and hippocampus. The β-amyloid cascade (Aβ) and post-translational modification of tau protein are considered the most important hypotheses of the causes of AD. In response to Aβ deposition, microglia and astrocytes release inflammatory cytokines (IL-1, IL-6, IL-10, TNF-α, IF-ɣ) in order to regulate the intensity and duration of neuroinflammation. Leptin is related to a decrease in Aβ levels by attenuating its production and increasing its clearance as well as attenuating tau protein phosphorylation. Objective: The aim of this study was to verify the serum inflammatory process in AD patients and non-demented elderly. Methodology: This is a case-control study composed of elderly with AD without dementia. For IL-1, IL-6, IL-10, TNFα, IF-γ dosing, a commercial Proteintech® ELISA kit was used and for serum leptin dosing a Raybio® commercial ELISA kit was used. Nutrition Mini-Assessment (NMA) and Body Mass Index (BMI) were used to assess nutritional status in both groups. Results: The results showed that elderly with AD had worse nutritional status (p <0.001) and mental status (p <0.001) when compared to participants in the control group. In addition, serum IL-1, IL-6, TNF-α and INF-ɣ levels were statistically higher in the AD patient groups, while serum IL-10 and Leptin levels were statistically lower in the AD patient groups. A negative correlation was observed between BMI and leptin (R2: 0.6425; p <0.05) in the AD group. Conclusion: Given the results obtained, it is suggested that an systemic inflammatory response may occur in elderly with AD, by increasing the levels of proinflammatory cytokines IL-1, IL-6, TNF-α and IFN-γ; in addition to changes in body composition and leptin levels. |
