Síntese de derivados de chalconas e de 2-quinolinonas visando a busca por inibidores das enzimas cruzaína e da família BET bromodomain

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Vieira, Lucas Campos Curcino
Orientador(a): Corrêa, Arlene Gonçalves lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Tese
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Universidade Federal de São Carlos
Programa de Pós-Graduação: Programa de Pós-Graduação em Química - PPGQ
Departamento: Não Informado pela instituição
País: BR
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: https://repositorio.ufscar.br/handle/20.500.14289/6314
Resumo: The first part of this work involved the synthesis of chalcone derivatives towards the development of inhibitors of the enzyme cruzain from Trypanosoma cruzi. Different green chemistry approaches were employed to functionalize chalcones as the use of alternative solvents as well as source of energy. A new Suzuki cross-coupling methodology for synthesis of functionalized chalcones was developed, employing PEG-400 as solvent under microwave irradiation. The use of organocatalysis in the 1,4-addition of α,α-dicyanoolefins to α,β- unsaturated carbonyl system provided products with good yields and excellent enantiomeric excess. It was also developed a new synthetic route for the synthesis of γ-butenolides from chalcones. The key step was accomplished using montmorillonite K10 clay as catalyst and ethanol as solvent... (CONTINUE)