Preparação de filmes de quitosana e PLGA com polipirrol para aplicação na regeneração nervosa

Detalhes bibliográficos
Ano de defesa: 2014
Autor(a) principal: Pilar, Fabiana Dias lattes
Orientador(a): Basso, Nara Regina de Souza lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
Programa de Pós-Graduação: Programa de Pós-Graduação em Engenharia e Tecnologia de Materiais
Departamento: Faculdade de Engenharia
País: BR
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/3271
Resumo: The purpose of this research was to prepare biocompatible and absorbable polymeric composites films of chitosan and PLGA with PPy nanofibers for application in peripheral nerve regeneration. The QT and PLGA films were prepared by solvent evaporation technique and PPy was synthesized by chemical oxidative polymerization using PTSA as dopant agent. In order to check the degradation time of the films, were performed a in vitro degradation tests. The nanofibers and PPy films produced were characterized by Scanning Electron Microscopy (SEM), Infrared Spectroscopy Fourier Transform (ATR / FT-IR), Thermal Gravimetric Analysis (TGA), Atomic Force Microscopy (AFM), X-ray Computed Microtomography (μCT), Electrical Impedance Spectroscopy (EIS) and Electrometer. The PPy nanofibers synthesized showed a conductivity of 8x10-4 S/cm and the PLGA - PPy film produced showed a conductivity of 1x10-7 S/cm. The addition of PPy nanofibers accelerated the degradation of the composite films when compared to the array and significantly changed the morphology of the films of PLGA and QT, forming frameworks that may promote nerve regeneration.