Associação entre biomarcadores e desfecho clínico em pacientes com COVID-19 admitidos em UTI

• Ano de defesa: 2023
• Autor(a) principal: Santos, Patrícia Silva dos
• Orientador(a): Oliveira, Jarbas Rodrigues de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Biologia Celular e Molecular
• Departamento: Escola de Ciências Saúde e da Vida
• País: Brasil
• Palavras-chave em Português: COVID-19; SARS-CoV-2; Biomarcadores; Desfecho; UTI
• Área do conhecimento CNPq: CIENCIAS BIOLOGICAS::BIOLOGIA GERAL
• Link de acesso: https://tede2.pucrs.br/tede2/handle/tede/10749

Context: The COVID-19 pandemic, caused by the severe acute respiratory syndrome virus 2 (SARS-CoV-2), has had major impacts on society and in numerous contexts. Faced with this moment, which challenges modern medicine with the increasing admission of patients to the Intensive Care Unit (ICU) and the increase in mortality, a better understanding of the association of biomarkers associated with the outcome of the disease is necessary. We aimed to analyze the association between biomarkers, from patients infected with SARS-CoV-2 obtained upon admission to the ICU, and the clinical outcome. Materials and methods: In this cross-sectional study, we included 60 patients diagnosed with COVID-19 admitted to the ICU. Demographic data, clinical history and investigation of biomarkers collected at admission were analyzed. Patients were evaluated based on the clinical outcome: hospital discharge or death. Results: The mean age of the hospital discharge group (62.50 ± 12.39) was lower than that of the death group (69.29 ± 12.7). Procalcitonin, creatinine, and urea levels were significantly higher in the death group compared to the hospital discharge group. Albumin and glucose levels were lower in the death group compared to the hospital discharge group (p<0.05). Conclusion: Age and the laboratory biomarkers procalcitonin, urea, creatinine, albumin and glucose obtained from patients infected with SARS-CoV2 on admission to the ICU were significantly associated with clinical outcome. Patients with high levels of procalcitonin have a 3.5 times greater risk of progressing to death and premature outcome compared to patients with normal levels.