Medidas ultrassonográficas de gordura abdominal e medidas ultrassonográficas automatizadas da espessura médio-intimal carotídea em adolescentes obesos

• Ano de defesa: 2013
• Autor(a) principal: Lazaretti, Arthur Silva
• Orientador(a): Baldisserotto, Matteo
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina/Pediatria e Saúde da Criança
• Departamento: Faculdade de Medicina
• País: BR
• Palavras-chave em Português: OBESIDADE; ULTRASSONOGRAFIA; INSULINA; ADOLESCENTES; GORDURA ABDOMINAL
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/1422

Importance: Obesity has become a major public health problem due to its growing prevalence in recent decades and its comorbidities. Many studies have related abdominal fat to metabolic abnormalities and increased risk of cardiovascular diseases in adults, but there are few studies that have examined these questions in adolescents. Atherosclerotic disease is the major cause of morbidity and mortality around the world. Atherosclerosis has been demonstrated to begin in childhood and measurement of carotid artery intima-media thickness (cIMT) by ultrasonography (US) can be used to evaluate cardiovascular risk in this population. Whether the thickness of arterial wall increases with body mass index (BMI) is still a matter of debate. Objective: The purpose of this study was to assess the association between ultrasound measurements of abdominal fat and automated US measurements of cIMT with anthropometric and laboratory data in a group of adolescents in order to identify potential markers that may be used to control the development of risk factors for cardiovascular disease in adolescents. Patients and Methods: Forty-five patients aged 10 to 17 years were enrolled in this study voluntarily. The subjects were evaluated in a pediatric outpatient clinic at either the Instituto da Criança da Universidade de São Paulo in São Paulo or the Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul in Porto Alegre. Adolescents were classified as obese or eutrophic according to their body mass index z-score for Brazilian children and adolescents. We determined waist circumference, waist-to-height ratio and conicity index from all subjects. We obtained blood samples from all subjects after 12 hours of fasting to measure glycemia, triglyceride, total cholesterol, HDL-cholesterol, LDL-cholesterol, insulin, and apolipoprotein B levels. We calculated the patients HOMA-IR index, a mathematical model that quantifies insulin resistance based on the formula: HOMA-IR = fasting Insulin (μUI/mL) x fasting glucose (mmol/L) / 22.5. All patients received an ultrasound assessment of subcutaneous tissue, pre-peritoneal fat, and intra-abdominal fat and all of them received an US assessment of the common carotid artery intima-media thickness. Results: Ultrasonographic measures of abdominal fat were found to be associated with anthropometric measurements, glucose level, insulin level, and HOMA-IR (except glucose and maximal pre-peritoneal fat). In our multivariate analysis, body mass index z-score, conicity index, and HOMA-IR remained independently associated with the subjects sum of fat. Only minimal subcutaneous fat associated independently with HOMA-IR. In relation to the vascular US evaluation, cIMT was not associated with sex or BMI z-score. However, cIMT on both the right and the left sides was found to associate positively with height. Additionally, cIMT on the right side was found to associate positively with waist circumference and HOMA-IR, and negatively with apolipoprotein B levels. In our multivariate analysis, only height remained independently associated with cIMT (right and left). Conclusions: Subcutaneous fat may be more useful than visceral fat as a marker for insulin resistance in adolescents. In the US measurements of both cIMT, only height was independently associated with this automated method. Further studies should be conducted on a prospective basis in order to identify potential markers that could be used to prevent the development and progression of cardiovascular pathology in pediatric patients.