Associação entre hormônios tireoideanos e temperamento

Detalhes bibliográficos
Ano de defesa: 2009
Autor(a) principal: Kist, Luiza Wilges lattes
Orientador(a): Lara, Diogo Rizzato lattes
Banca de defesa: Não Informado pela instituição
Tipo de documento: Dissertação
Tipo de acesso: Acesso aberto
Idioma: por
Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
Programa de Pós-Graduação: Programa de Pós-Graduação em Biologia Celular e Molecular
Departamento: Faculdade de Biociências
País: BR
Palavras-chave em Português:
Área do conhecimento CNPq:
Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/5335
Resumo: Temperament is the automatic emotional and motivational bias, influencing mood, behavior and personality development. Thyroid dysfunction is more prevalent in patients with mood disorder and may interfere with treatment responsiveness, but the relationship between thyroid function and temperament has been less studied. Methods: 143 subjects (103 females) who completed the Combined Emotional and Affective Temperament Scale were evaluated for TSH, free T4 and free T3 levels. Results: There was a significantly higher proportion of cyclothymics than euthymics in the high TSH group (>4 mIU/L, p<0.05). Female volunteers with TSH<4 mIU/L had significantly higher scores for anxious and lower scores for irritable temperaments. Among volunteers with TSH<4 mIU/L, there was a positive correlation of free T4 with apathetic temperament score (r=0.23, p<0.01). This correlation persisted in males (r=0.33, p=0.037) and females (r=0.22, p=0=0.026) and if only volunteers with no medication at all were included (r=0.23, p=0.015, n=108). Conclusion: Thyroid hormones seem to be associated with temperament in a non-linear way. Findings in patients with mood disorders and subclinical hypothyroidism cannot be generalized to understand the physiological role of thyroid hormones on emotion and affect.