"Avaliação da expressão imunoistoquímica do fator tecidual no carcinoma de pênis"

• Ano de defesa: 2014
• Autor(a) principal: Fay, Carlos Eduardo Schio
• Orientador(a): Carvalhal, Gustavo Franco
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina e Ciências da Saúde
• Departamento: Faculdade de Medicina
• País: BR
• Palavras-chave em Português: MEDICINA; NEOPLASIAS DOS GENITAIS MASCULINOS; TROMBOPLASTINA; IMUNOISTOQUÍMICA
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/1773

Purpose: Increased expression of tissue factor (TF) was correlated with worse prognosis and survival in various malignant neoplasms. In urologic tumors, it was studied in prostate, bladder and kidney cancers. The present study evaluates the immunohistochemical expression of TF in human penile cancer, correlating it with prognostic factors and survival. Materials and Methods: A total of 34 patients were treated by partial or total penectomy for penile carcinoma at our institution from January 1998 to December 2012. The immunohistochemical expression of TF was determined by a quantitative methodology in formalin-fixed paraffin-embedded tissue samples and correlated with age, clinical stage, pathologic stage, lymph node metastases, tumor grade and survival. Results: Immunohistochemical expression of TF was observed in 26/34 (76.4%) specimens. The mean area of TF expression in the samples was 27.82 μm2 [95% CI 20.0 35.6, SD 22.4]. Mean age was significantly lower among patients with increased TF expression in comparison to those with lower TF expression [57.6 (SD 9,9) vs. 67.3 years (SD 16,4); p = 0.047). Mean postoperative follow-up was 28.3 months (from 1 to 139.6 months). There were eight deaths (23.5%), four in each group, all related to the penile cancer. In multivariate analyses, there was no statistically significant correlation between TF expression and the study variables. Conclusions: TF was expressed in most samples of penile cancers. There was no statistically significant correlation between TF expression, prognostic factors and survival.