Detalhes bibliográficos
| Ano de defesa: |
2014 |
| Autor(a) principal: |
Maggioni, Lucas Spadari |
| Orientador(a): |
Padoin, Alexandre Vontobel
 |
| Banca de defesa: |
Não Informado pela instituição |
| Tipo de documento: |
Tese
|
| Tipo de acesso: |
Acesso aberto |
| Idioma: |
por |
| Instituição de defesa: |
Pontifícia Universidade Católica do Rio Grande do Sul
|
| Programa de Pós-Graduação: |
Programa de Pós-Graduação em Medicina e Ciências da Saúde
|
| Departamento: |
Faculdade de Medicina
|
| País: |
BR
|
| Palavras-chave em Português: |
|
| Área do conhecimento CNPq: |
|
| Link de acesso: |
http://tede2.pucrs.br/tede2/handle/tede/1772
|
Resumo: |
The pathogenesis of nonalcoholic fatty liver disease (NAFLD) is not completely elucidated. There is increasing evidence that oxidative stress is involved in this process. The objective of the present study was to evaluate the role of plasma markers of oxidative stress in morbidly obese patients with NAFLD. Forty-three morbidly obese patients were subjected to Roux-en-Y gastric bypass with a liver biopsy obtained during surgery. Plasma oxidative stress was measured by thiobarbituric acid reactive substances (TBARS) and superoxide dismutase (SOD) assays. Histologic analysis showed NASH in 65.1% of patients and simple steatosis in 34.9%. The plasma TBARS levels were significantly greater in the patients with NASH when compared to those with simple steatosis [1.65 (1.43-1.82) nM/ml vs 1.12 (1.04-1.42) nM/ml; P=0.002]. There was a correlation of TBARS with NAS score (rs = 0.470; P = 0.001). Among the patients with NASH and simple steatosis, there was no difference in plasma antioxidant status measured by SOD. Our findings suggest that plasma lipid peroxidation is associated with the severity of NAFLD in the morbidly obese patients |
