Níveis da quimiocina RANTES na placenta, plasma materno e plasma do cordão umbilical em gestantes normais e com síndrome de pré-eclâmpsia

• Ano de defesa: 2012
• Autor(a) principal: Silveira, Ilson Dias da
• Orientador(a): Costa, Bartira Ercília Pinheiro da
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul
• Programa de Pós-Graduação: Programa de Pós-Graduação em Medicina e Ciências da Saúde
• Departamento: Faculdade de Medicina
• País: BR
• Palavras-chave em Português: MEDICINA; PLACENTA; PLASMA; CITOCINAS; PRÉ-ECLÂMPSIA; GESTAÇÃO; CORDÃO UMBILICAL; MARCADORES BIOLÓGICOS
• Área do conhecimento CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA
• Link de acesso: http://tede2.pucrs.br/tede2/handle/tede/1706

Objective: To estimate RANTES levels at maternal plasma, umbilical cord blood plasma and placenta in preeclampsia syndrome and normal pregnancy. Methods: A cross-sectional study was conducted to estimate RANTES levels in maternal plasma, placenta and cord blood plasma in preeclampsia syndrome (n=33) compared to a control group of women with normal pregnancy (n=36) attended at São Lucas Hospital/PUCRS, Porto Alegre, RS Brazil. Concentrations of RANTES were measured using a human RANTES ELISA assay. Results: Women with preeclampsia syndrome showed significantly higher RANTES levels in plasma and placenta in comparison to women with normal pregnancy (P<0.01). The cord blood plasma of infants born from women with preeclampsia syndrome had a significantly decreased RANTES levels compared to infants born from a normal pregnancy (P<0.01). The concentration of placental RANTES was positively correlated with RANTES in the maternal plasma (Pearson´s correlation r= 0.697; p<0.001), and negatively with the cord blood plasma (r= -0.818; p<0.001). A strong negative correlation was also demonstrated between maternal plasma and cord blood plasma RANTES (r= -0.751, p<0.001). Conclusion: This study shows a distinct inflammatory response between mother and new born in preeclampsia syndrome and normal pregnancy. In preeclampsia syndrome maternal plasma and placenta displayed increased pro-inflammatory RANTES cytokine concentration, however a reduced levels were detected in the umbilical cord plasma from women with preeclampsia syndrome, suggesting a fetal antiflammatory response.