Citotoxicidade e genotoxicidade de materiais ortodônticos

• Ano de defesa: 2009
• Autor(a) principal: Westphalen, Graziela Henriques
• Orientador(a): Menezes, Luciane Macedo de
• Tipo de documento: Tese
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: ODONTOLOGIA; ORTODONTIA; ORTOPEDIA FACIAL; MATERIAIS DENTÁRIOS; TOXICIDADE
• Link de acesso: http://hdl.handle.net/10923/370

Biocompatibility evaluation of orthodontic materials is very important, since some constituent elements of these materials are related to citotoxic, genotoxic and carcinogenic effects. This study aimed to assess citotoxicity and genotoxicity of orthodontic materials. Citotoxicity of orthodontic materials (brackets, wires, resin composites, solder silver and elastomers) was tested by two survival exposure to Saccharomyces cerevisiae (S. Cerevisiae), through direct and indirect (chemical products liberated by these materials in artificial saliva) forms (Article 1). Assessment of genotoxicity was carried out in patient groups, using the following tests: Cytome buccal micronucleus assay for evaluating orthodontic fixed appliances and Hyrax (Article 2), Micronucleus tests for Hyrax and Haas appliances (Article 3). For Article 1, occurrence of S. Cerevisiae survival was compared in a semi-log curve between orthodontic materials and control groups. For articles 2 and 3, non parametric test was used (ES0. 05%) for comparison among patients and control groups. Silver solder was the only material that showed citotoxicity. All appliances tested did not present genotoxicity in studied patients.