Velocidade de transporte peritoneal e níveis séricos de glicose e insulina de pacientes em diálise peritoneal

• Ano de defesa: 2006
• Autor(a) principal: Silva, Dirceu Reis da
• Orientador(a): D'Avila, Domingos Otávio Lorenzoni
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: MEDICINA; DIÁLISE PERITONEAL; INSUFICIÊNCIA RENAL; GLICEMIA; INSULINA
• Link de acesso: http://hdl.handle.net/10923/4537

Objective: To observe the variations in serum glucose and insulin levels induced by the peritoneal exposition to glucose solution during a peritoneal equilibration test (PET), and to relate the findings with the solutes peritoneal transport rate. Patients and Method: A cross-sectional, observational, study using a modified PET procedure (4,25% glucose solution) that enrolled 34 prevalent peritoneal dialysis patients. Glucose and insulin serum levels were sequentially determined (at zero, 15, 30, 60, 120, 180, and 240 minutes) along the procedure, and an insulin resistance index (IR-HOMA) was computed. Categories of peritoneal transport were separated by quartiles of the dialisate/serum creatinine rate after 240 minutes of peritoneal exposition to the infused fluid (D4/PCr). Demographic and clinical variables were examined, and possible correlations among variables and categories of peritoneal transport were tested. Results: No difference for IR-HOMA, glucose and insulin levels was demonstrated among peritoneal transport categories. A direct correlation between the early glucose, and insulin peak increment and D4/PCr was evidenced. IR-HOMA was associated with the body mass index. Conclusion: Early glucose and insulin peak increment were associated with the solutes transport rate, as measured by the PET. The meaning of the findings on the outcome of patients with high peritoneal transport rate must be further evaluated.