Efeito das drogas anticonvulsivantes na densidade mineral óssea

• Ano de defesa: 2006
• Autor(a) principal: Momm, Silvana
• Orientador(a): Souza, Antônio Carlos Araújo de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Pontifícia Universidade Católica do Rio Grande do Sul; Porto Alegre
• Palavras-chave em Português: MEDICINA; DENSIDADE ÓSSEA; GERIATRIA; OSTEOPOROSE; ANTICONVULSIVOS
• Link de acesso: http://hdl.handle.net/10923/4337

Long term therapy with antiepileptic drugs (AED) is related to decreased mineral bone density and increased risk of osteoporotic fractures. Objective: To investigate bone mass in patients with 40 years old or more, who have been using AED for at least 5 years. Patients and Methods: Sixty outpatients, 33 males and 27 females, adults, who have been using AED for at least 5 years were compared to a control group composed of 65 health adults, l6 males and 49 females who have never used AED. Bone density was measured by using dual-energy x-ray absorptiometry, such as sunlight exposure, calcium intake and physical activity with all those patients. Results: BMD (g/cm2), of the femoral neck and lumbar spine (L1-L4) of the AED users and the control group were evaluated separately for male and female. In the femoral neck, the difference between AED male users and control group was respectively 0,902 (±0,139) and 0,934 (±0,098) p= NS; for females was 0,855 (±0,126) and 0,894 (±0,099) p=NS, In lumbar spine, the difference between AED male users and control group was 1,079 (±0,191) and 1,255 (±0,199) p<0,05; for females was l,024 (±0,151) and 1,110 (±0,113) p<0,05. Conclusion: The study concluded that BMD in an adult group of patients, users of AED for five years or more, compared to the control group was significantly lower in lumbar spine but in femoral neck no significant difference was shown.