Efeitos clínicos e analgésicos da administração epidural da dexmedetomidina associada à lidocaína em cadelas submetidas à ovário-histerectomia

• Ano de defesa: 2011
• Autor(a) principal: Marquetti, Mércia Amaro
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade de Franca; Brasil; Pós-Graduação; Programa de Mestrado em Medicina Veterinária de Pequenos Animais; UNIFRAN
• Palavras-chave em Português: Cadela; Dor; Agonista-receptor-alfa-2-adrenérgico; CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA::CLINICA E CIRURGIA ANIMAL
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/684

The spinal cord has an important role in the mechanism of transmission of nociceptive impulses. The block of these impulses interrupt or minimize the pain derived from the release of inflammatory mediators harmful to the body. Thus, administration of drugs in this region has been used both for anesthetic blocks and for prevention of postoperative pain. This study aimed to evaluate the analgesic and time effects of dexmedetomidine with lidocaine, administered epidurally, during the postoperative period in female dogs underwent to ovariohysterectomy (OHE). For this purpose it was used 20 adult female dogs, healthy, separated into two groups. In GLIDO group it was applied epidurally 0.25 ml/kg of 2% lidocaine without vasoconstrictor associated with sodium chloride 0.9%, and in GDEX group it was administered lidocaine without vasoconstrictor, in the same dose, associated with 2 μg/kg of dexmedetomidine. The surgeon was the same in all procedures and evaluation began in the postoperative period immediately after extubation and every 30 minutes during six hours. It was evaluated objective and subjective parameters: visual analogue scale (VAS), behavioral scale, heart rate (HR), respiratory rate (RR), rectal temperature (RT), systolic arterial pressure (SAP) and the time of additional analgesia required. For HR, GLIDO was significantly higher than GDEX in T0 and T30. Respiratory rate was different between groups only 60 minutes after the beginning of the evaluation, and GLIDO was higher than GDEX. In addition, T300 was higher than T0 in GDEX. RT increased gradually throughout the evaluation period in GDEX. In the analgesic evaluation thought behavioral table and visual analogue scale higher scores were observed in GDLIDO when compared to GDEX, with significant difference in VAS at T0, T30, and T90, representing more pronounced response to pain. The analgesia in GLIDO animals lasted 150 minutes and in GDEX 360 minutes. It was concluded that dexmedetomidine associated with lidocaine epidurally is a secure technique, with better quality of anesthesia recovery and longer postoperative analgesia.