Avaliação do efeito antimicrobiano in vitro de um sérum pós-microagulhamento contendo oleorresina de copaíba frente a microrganismos da pele

• Ano de defesa: 2022
• Autor(a) principal: Castellane, Jéssica Aline de Souza
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade de Franca; Brasil; Pós-Graduação; Programa de Mestrado em Ciências; UNIFRAN
• Palavras-chave em Português: Atividade antimicrobiana; Oleorresina de copaíba; Microagulhamento; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/3763

A current and less invasive alternative for the treatment of skin imperfections is the percutaneous induction of collagen by microneedling. This procedure basically consists of creating micro lesions on the skin to provide damage to old collagen fibers and boost tissue restoration. However, the microchannels formed during this treatment have the potential to facilitate the access of microorganisms to the interior of the skin, increasing the susceptibility to skin infection. Copaiba oleoresin is a product of secondary metabolism of species of the genus Copaifera and has proven antimicrobial activity. In this sense, the present study aimed to evaluate the in vitro antimicrobial potential of a commercial product under development (Ekobé do Brasil post-microneedling serum) against a panel of microorganisms representative of the human skin microbiota by determining the Minimum Inhibitory Concentration (MIC), Minimum Bactericidal Concentration (MBC) and Minimum Fungicide Concentration (MFC). Through the methodology used in this evaluation, it was possible to determine that the product was active with MIC/MBC in the range of 0.047 to 3.000% for all bacteria tested and with MIC/MFC in the range of 0.012 to 0.094 for yeasts. Thus, based on the results of the in vitro antimicrobial activities described in this work, it is possible to conclude that the post-microneedling serum evaluated has antimicrobial potential to mitigate the risk of infection involved in this type of procedure. Key-words: microneedling, antimicrobial activity, copaiba oilresin