Avaliação da eficácia in vitro e ensaio clínico de extrato de Scutellaria baicalensis Georgi , Glycine max L. e Triticum vulgare Vill para o tratamento da alopecia androgenética

• Ano de defesa: 2018
• Autor(a) principal: Ribas, Flávia Bogo
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Positivo; Brasil; Pós-Graduação; Programa de Pós-Graduação em Biotecnologia Industrial; UP
• Palavras-chave em Português: Biotecnologia Industrial; Alopecia; Scutellaria baicalensis; Feijão de Soja; Triticum; CNPQ::CIENCIAS BIOLOGICAS::BIOLOGIA GERAL
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2272

Androgenetic alopecia is a condition that affects men more, because hair loss in this case is usually associated with the presence of male sex hormones, especially the presence of testosterone. Characterized by miniaturization of the hair follicles, reduction of the anagen phase of the capillary cycle and increase of the telogen phase, this pathology usually generates negative psychological consequences, leading to low self-esteem and even depression. The objective of this work is to contribute to a better understanding of androgenetic alopecia through a literature review, and to provide an effective treatment option for this pathology. In vitro study with the extract of Scutellaria baicalensis Georgi was performed to verify the delay of cellular senescence, a factor that aggravates this capillary pathology. Clinical trials with the combination of extracts of Scutellaria baicalensis Georgi, Glycine max L. and Triticum vulgare Vill were performed to verify capillary density by image analysis and perceived efficacy with two groups of male volunteers: group 1, 11 volunteers applied a capillary lotion containing a combination of extracts at 4% 1x per day, group 2, 11 volunteers applied a placebo capillary lotion 1x per day. With the in vitro study we can conclude that the extract of Scutellaria baicalensis Georgi delays the entry of the cells of the hair follicle in the senescent state, extending the active life of the cells by 10%. In the in vivo clinical studies, there was no statistical evidence that the treatment presented a difference in comparison when compared to the control group.