Associação entre a qualidade de vida e polimorfismos do gene do estrógeno em pacientes com deformidade dentofacial

• Ano de defesa: 2019
• Autor(a) principal: Machado, Nilza Cristina da Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Positivo; Brasil; Pós-Graduação; Programa de Pós-Graduação em Odontologia Clínica; UP
• Palavras-chave em Português: Odontologia; Arcada Osseodentária - Anormalidades; Estrógenos; Qualidade de vida; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2238

Introduction: Qualified quality of life in oral health is the absence of negative impacts of oral conditions on social life and positive feeling of self-confidence. Dentofacial deformity (DDF) is known to alter the perception of QOL of individuals. The estrogen transport genes (ESR1 and ESR2) may be associated with these perceptions and their variations may have a negative impact on quality of life oral health, causing severe functional and psychosocial problems. Objective: To evaluate an association between QOL and oral health and estrogen transport gene polymorphisms in patients with DDF. Materials and methods: The study included 234 adult male and female patients with FDD who underwent orthognathic surgery. To assess the perception of QOL, the oral health used was the Oral Health Impact Profile (OHIP-14); gender, age and facial profile were also applied. In addition, oral mucosa cells were collected for DNA extraction. The estrogen transport genes ESR1 (rs2234693, rs9340799) and ESR2 (rs1256049 and rs4986938) were genotyped by real time PCR technique. The results were submitted to statistical analysis, with a significance level of 0.05. Results: It was observed that age was associated with the perception of QOL. Patients older than 28 years have a worse perception of QOL with overall oral health (p = 0.003). The association between OHIP-14 and sex shown as women with DDF has a worse perception of overall QOL when compared to men (p <0.001). In the analysis between the perception of QoL and the results shown by the DDF, it was observed that Profile II had a worse perception of QoL in the domain of social disability, compared with profile III (p = 0.030). There was an association between the rs9340799 polymorphism and a perception of quality of life in the domain of functional limitation and social disadvantage. Conclusion: Age, sex, facial profile and rs9340799 polymorphism alter the QOL of patients with DDF. Patients over 28 years of age have a worse perception of QOL related to oral health. Women with DDF have a worse perception of QOL. Facial profile II individuals had a worse perception of QOL compared to profile III individuals.