Influência da aplicação do gel de liberação lenta de oxigênio em modelo animal de BRONJ: estudo de boca dividida

• Ano de defesa: 2020
• Autor(a) principal: Cristo, Bruna Cristina de
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Positivo; Brasil; Pós-Graduação; Programa de Pós-Graduação em Odontologia Clínica; UP
• Palavras-chave em Português: Odontologia; Osteonecrose; Bifosfonatos; Oxigênio; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2144

The objective of this dissertation was to evaluate the effectiveness of the gel with slow release of oxygen in the prevention of osteonecrosis induced by bisphosphonates (Bisphosphonate Related Osteonecrosis of the Jaw - BRONJ). For this split-mouth study, 12 rats (6 males and 6 females) were used, with the right hemimmible of treatment (Test T Group) and left hemimible without treatment (Control Group C). For the development of osteonecrosis, zolendronate was used, via caudal, once a week, for 9 weeks at a dose of 80g/kg. Two surgical stages were performed, the first in the eighth week of application of bisphosphonate for the extraction of the first lower molars on both sides and alveole decorticalization. In the ninth week of zolendronate application, the second surgical stage was performed for the extraction of the lower second molars followed by alveolar decorticalization. The animals received topical application of oxygen gel in the right hemimandible (T) 3 times a week until euthanasia was performed after 6 weeks and no intervention in the left hemimandibula (C). The clinical parameters analyzed were the presence of inflammation, bone sequestration and epithelialization. The results were submitted to descriptive, numerical variable (qui-square test) and statistical (MannWhitney test, p<0.05). In group (C) a more severe condition was clinically observed on the day of euthanasia than the group (T). Within the limitations of the present study, we can conclude that the application of the gel with slow release of oxygen in the prevention of Bronj minimized the bone exposure of the wound.