Estudo da associação dos receptores dopaminérgicos D2(DRD2) e Ankyrin Repeat and Kinase Domain Containing 1 (ANKK1) em disfunções temporomandibulares de adolescentes

• Ano de defesa: 2018
• Autor(a) principal: Franco, Gizele Batista
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Instituição de defesa: Universidade Positivo; Brasil; Pós-Graduação; Programa de Pós-Graduação em Odontologia Clínica; UP
• Palavras-chave em Português: Odontologia; Articulação temporomandibular; Polimorfismo (Genética); Dopamina; CNPQ::CIENCIAS DA SAUDE::ODONTOLOGIA
• Link de acesso: https://repositorio.cruzeirodosul.edu.br/handle/123456789/2078

Background: Temporomandibular dysfunction (TMD) is considered a multifactorial condition involving environmental, psychological and genetic conditions. Objective: To investigate the association between genetic polymorphisms in the DRD2 and ANKK1 genes with TMD in a population of adolescents living in the city of Curitiba. Materials and Methods: In that case-control study were included 253 adolescents between 10 and 14 years. Of these, 148(case group) were diagnosed with TMD by the RDC/TMD criteria. The control group consists of 105 without TMD: The case group (TMD-affected) included individuals diagnosed with any of the following TMD subgroups according to the RDC/TMD criteria: myofascial pain (with or without limited opening), disc displacements (with and without reduction), and arthralgia. Genomic DNA for molecular analysis was extracted from buccal cells and genetic polymorphisms in DRD2 and ANKK1 were genotyped by real time polymerase chain reactions using the TaqMan assay. Results: There were no significant differences between the affected and unaffected individual (p>0.05) however, rs6275 in DRD2 was borderline in the allelic distribution (p=0.08). Recessive and dominant models also also did not show significant differences between the affected and unaffected individual (p>0.05) but rs6275 (p<0,05), rs6276 (p=0.07) and rs1800497 (p=0.06) were associated with disc displacement. Conclusion: Genetic polymorphisms in DRD2 and ANKK1 are not associated with myofascial pain, arthralgia or TMD in adolescents but this study provides evidence that these same genes are involved in the disc displacement of the temporomandibular joint. Keywords: Adolescents, Genetic, Polymorphisms. Temporomandibular disorder, TMD.