O papel da ativação do sistema imune neonatal no desenvolvimento de um comportamento relacionado a esquizofrenia: um estudo pré-clínico

• Ano de defesa: 2020
• Autor(a) principal: Flores, Aline
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Ativação imune neonatal; Comportamento relacionado a esquizofrenia; Transtornos psiquiátricos; LPS; Imune neonatal actiation; Schizophrenia-like behaviour; Psychiatric disorders
• Link de acesso: https://repositorio.animaeducacao.com.br/handle/ANIMA/15186

Introduction: Despite advances in medical care, neonatal immune activation continues to be a common and significant cause of mortality and morbidity among infants. Activation of the immune system during early life has been associated with an increased risk of schizophrenia in adulthood. Objective: The aim of this study was to evaluate schizophrenia-like behaviour in adult mice following neonatal imune activation. Methods: Neonatal male and female C57BL/6 mice at postnatal days 2-3 received an injection of 25 µg of lipopolysaccharide (LPS) or PBS as a placebo. Schizophrenia-like behaviour was induced by ketamine (25, 50, or 100 mg/kg) at postnatal day 28. Tests of locomotor activity, stereotyped behaviour, and social interactions were conducted 30 min after injection of ketamine or saline. Results: Young adult mice that received ketamine in a dose of 50 mg/kg showed an increase in locomotor activity; stereotype scores and contact latency were also significantly higher compared with the control group that received the same ketamine dose. Conclusion: We conclude that exposure to imune neonatal activation during the neonatal period can cause alterations in normal brain development and trigger schizophrenia-like behaviour in adulthood.