Detalhes bibliográficos
Ano de defesa: |
2020 |
Autor(a) principal: |
Flores, Aline |
Orientador(a): |
Não Informado pela instituição |
Banca de defesa: |
Não Informado pela instituição |
Tipo de documento: |
Dissertação
|
Tipo de acesso: |
Acesso aberto |
Idioma: |
por |
Instituição de defesa: |
Não Informado pela instituição
|
Programa de Pós-Graduação: |
Não Informado pela instituição
|
Departamento: |
Não Informado pela instituição
|
País: |
Não Informado pela instituição
|
Palavras-chave em Português: |
|
Link de acesso: |
https://repositorio.animaeducacao.com.br/handle/ANIMA/15186
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Resumo: |
Introduction: Despite advances in medical care, neonatal immune activation continues to be a common and significant cause of mortality and morbidity among infants. Activation of the immune system during early life has been associated with an increased risk of schizophrenia in adulthood. Objective: The aim of this study was to evaluate schizophrenia-like behaviour in adult mice following neonatal imune activation. Methods: Neonatal male and female C57BL/6 mice at postnatal days 2-3 received an injection of 25 µg of lipopolysaccharide (LPS) or PBS as a placebo. Schizophrenia-like behaviour was induced by ketamine (25, 50, or 100 mg/kg) at postnatal day 28. Tests of locomotor activity, stereotyped behaviour, and social interactions were conducted 30 min after injection of ketamine or saline. Results: Young adult mice that received ketamine in a dose of 50 mg/kg showed an increase in locomotor activity; stereotype scores and contact latency were also significantly higher compared with the control group that received the same ketamine dose. Conclusion: We conclude that exposure to imune neonatal activation during the neonatal period can cause alterations in normal brain development and trigger schizophrenia-like behaviour in adulthood. |