Doenças alérgicas em crianças e adolescentes portadores de HIV/Aids

• Ano de defesa: 2013
• Autor(a) principal: Linhar, Leandro da Silva
• Tipo de documento: Dissertação
• Tipo de acesso: Acesso aberto
• Idioma: por
• Palavras-chave em Português: Crianças; Adolescentes; Doenças alérgicas; IgE; HIV/Aids
• Link de acesso: https://repositorio.animaeducacao.com.br/handle/ANIMA/3024

In the past decades, there has been a global raise in the prevalence of allergic diseases and, in parallel, suggestive manifestations of such diseases have been observed in patients with Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/Aids), however, there are few studies concerning the pediatric population. Objective: estimating the prevalence of allergic diseases on subjects under 18 years old who have HIV/Aids in the Association of Municipalities of Laguna Region (AMUREL) region and relating clinical-immunological characteristics of infection and atopy. Methods: a cross sectional study has been carried out with 29 outpatient aged under 18 years old followed in the HIV/Aids specialized clinic of the region, from February to October 2012. A questionnaire of the International Study for Asthma and Allergies in Childhood (ISAAC) protocol has been applied, data collection from the medical records investigating socio-demographic and laboratory data. Blood has been collected for total IgE serum dosage and Radioallergosorbent Test (RAST) for mites, cockroaches, and epithelium of animals, feathers, and fungi. The data were compiled on the computerized base of Excel 2007 and the analysis was carried out on the Prism 6 program. The following tests were applied: t-student test, chi-squared test, Fisher’s exact test and Mann-Whitney U test, when indicated, where values of p<0,05 were considered significant. Results: among the 29 evaluated individuals, the prevalence of symptoms of allergic diseases was 65.5% (IC95% 56.1-74.8), rhinitis being the most frequent 44.8% (IC95% 35.0-54.5), followed by asthma 37.9% (IC95% 28.3-47.4) and eczema 27.6% (IC95% 18.8-36.3). The RAST test was positive in 20.7% of the individuals with no significant difference among the groups. There was no significant difference concerning total IgE serum levels among individuals with and without records of allergic disease symptoms. Nevertheless, a high frequency of elevated total IgE measures 40.7% and a relation between elevated IgE and clinical stage of the HIV/Aids disease have been observed. A relation between CD8+ cell count and the prevalence of allergic diseases symptoms has also been obtained (p=0.014). Conclusion: there has been a high prevalence of allergic disease as well as high frequency of elevated total IgE serum. The relation elevated IgE with clinical stage deserves future inquiry, with serial measurements of total IgE serum for the identification of aggravation of HIV/Aids. The association between CD8+ count and prevalence of allergic diseases symptoms corroborates studies that have proved the role of these cells in the development of allergic diseases.