Dendritic cells : a double-edged sword in immune responses during chagas disease
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| Hoofdauteur: | |
|---|---|
| Publicatiedatum: | 2016 |
| Andere auteurs: | , , , |
| Formaat: | Article |
| Taal: | eng |
| Bron: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/23883 https://dx.doi.org/10.3389/fmicb.2016.01076 |
Samenvatting: | Dendritic cells (DCs) are the most important member of the antigen presenting cells group due to their ability to recognize antigen at the infection site and their high specialized antigen internalization capacity. These cells have central role in connecting the innate and adaptive immune responses against Trypanosoma cruzi, the causative agent of Chagas disease. These first line defense cells modulate host immune response depending on type, maturation level, cytokine milieu and DC receptor involved in the interactions with T. cruzi, influencing the development of the disease clinic forms. Here, we present a review of DCs–T. cruzi interactions both in human and murine models, pointing out the parasite ability to manipulate DCs activity for the purpose of evading innate immune response and assuring its own survival and persistence. |
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|---|---|
| author | Jaramillo, Natalia Gil |
| author2 | Motta, Flávia Nader Favali, Cecilia Beatriz Fiuza Bastos, Izabela Marques Dourado Santana, Jaime Martins de |
| author2_role | author author author author |
| author_browse | Bastos, Izabela Marques Dourado Favali, Cecilia Beatriz Fiuza Jaramillo, Natalia Gil Motta, Flávia Nader Santana, Jaime Martins de |
| author_facet | Jaramillo, Natalia Gil Motta, Flávia Nader Favali, Cecilia Beatriz Fiuza Bastos, Izabela Marques Dourado Santana, Jaime Martins de |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio2.unb.br/jspui/bitstream/10482/23883/1/ARTIGO_DendriticCellsDoubleEdged.pdf http://repositorio2.unb.br/jspui/bitstream/10482/23883/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Jaramillo, Natalia Gil Motta, Flávia Nader Favali, Cecilia Beatriz Fiuza Bastos, Izabela Marques Dourado Santana, Jaime Martins de |
| dc.date.accessioned.fl_str_mv | 2017-07-25T17:41:00Z |
| dc.date.available.fl_str_mv | 2017-07-25T17:41:00Z |
| dc.date.issued.fl_str_mv | 2016-07-14 |
| dc.identifier.citation.fl_str_mv | JARAMILLO, Natalia Gil et al. Dendritic cells: a double-edged sword in immune responses during chagas disease. Frontiers in Microbiology, v. 7, Article 107, 14 jul. 2016. Disponível em: <http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full>. Acesso em: 21 jun. 2017. doi: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://dx.doi.org/10.3389/fmicb.2016.01076 |
| dc.identifier.uri.fl_str_mv | http://repositorio.unb.br/handle/10482/23883 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Frontiers |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Células dendríticas Antígenos Trypanosoma cruzi Chagas, Doença de |
| dc.title.pt_BR.fl_str_mv | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Dendritic cells (DCs) are the most important member of the antigen presenting cells group due to their ability to recognize antigen at the infection site and their high specialized antigen internalization capacity. These cells have central role in connecting the innate and adaptive immune responses against Trypanosoma cruzi, the causative agent of Chagas disease. These first line defense cells modulate host immune response depending on type, maturation level, cytokine milieu and DC receptor involved in the interactions with T. cruzi, influencing the development of the disease clinic forms. Here, we present a review of DCs–T. cruzi interactions both in human and murine models, pointing out the parasite ability to manipulate DCs activity for the purpose of evading innate immune response and assuring its own survival and persistence. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_e86043b75bccde2e2144fc22388e94fc |
| identifier_str_mv | JARAMILLO, Natalia Gil et al. Dendritic cells: a double-edged sword in immune responses during chagas disease. Frontiers in Microbiology, v. 7, Article 107, 14 jul. 2016. Disponível em: <http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full>. Acesso em: 21 jun. 2017. doi: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
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| publishDate | 2016 |
| publishDateSort | 2016 |
| publisher.none.fl_str_mv | Frontiers |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Jaramillo, Natalia GilMotta, Flávia NaderFavali, Cecilia Beatriz FiuzaBastos, Izabela Marques DouradoSantana, Jaime Martins de2017-07-25T17:41:00Z2017-07-25T17:41:00Z2016-07-14JARAMILLO, Natalia Gil et al. Dendritic cells: a double-edged sword in immune responses during chagas disease. Frontiers in Microbiology, v. 7, Article 107, 14 jul. 2016. Disponível em: <http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full>. Acesso em: 21 jun. 2017. doi: http://journal.frontiersin.org/article/10.3389/fmicb.2016.01076/full.http://repositorio.unb.br/handle/10482/23883https://dx.doi.org/10.3389/fmicb.2016.01076FrontiersCopyright©2016Gil-Jaramillo,Motta,Favali,BastosandSantana.Thisisan open-accessarticledistributedunderthetermsofthe Creative Commons Attribution License (CCBY). Theuse,distributionorreproductioninotherforumsispermitted, providedtheoriginalauthor(s)orlicensorarecreditedandthattheoriginal publicationinthisjournaliscited,inaccordancewithacceptedacademicpractice. No use,distributionorreproductionispermittedwhichdoesnotcomplywiththese terms.info:eu-repo/semantics/openAccessDendritic cells : a double-edged sword in immune responses during chagas diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCélulas dendríticasAntígenosTrypanosoma cruziChagas, Doença deDendritic cells (DCs) are the most important member of the antigen presenting cells group due to their ability to recognize antigen at the infection site and their high specialized antigen internalization capacity. These cells have central role in connecting the innate and adaptive immune responses against Trypanosoma cruzi, the causative agent of Chagas disease. These first line defense cells modulate host immune response depending on type, maturation level, cytokine milieu and DC receptor involved in the interactions with T. cruzi, influencing the development of the disease clinic forms. Here, we present a review of DCs–T. cruzi interactions both in human and murine models, pointing out the parasite ability to manipulate DCs activity for the purpose of evading innate immune response and assuring its own survival and persistence.engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_DendriticCellsDoubleEdged.pdfARTIGO_DendriticCellsDoubleEdged.pdfapplication/pdf682969http://repositorio2.unb.br/jspui/bitstream/10482/23883/1/ARTIGO_DendriticCellsDoubleEdged.pdf74753be53cf423042a41a97e76ac09a1MD51open accessLICENSElicense.txtlicense.txttext/plain160http://repositorio2.unb.br/jspui/bitstream/10482/23883/2/license.txtcd7f2de909e07c008880b5201378c22eMD52open access10482/238832023-05-24 20:34:25.471open accessoai:repositorio.unb.br:10482/23883U3VibWlzcz9vIGVmZXRpdmFkYSBwb3IgaW50ZWdyYW50ZSBkYSBlcXVpcGUgZG8gUmVwb3NpdD9yaW8gSW5zdGl0dWNpb25hbCBkYSBVbkIgZGUgYWNvcmRvIGNvbSBsaWNlbj9hIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2023-05-24T23:34:25Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Dendritic cells : a double-edged sword in immune responses during chagas disease Jaramillo, Natalia Gil Células dendríticas Antígenos Trypanosoma cruzi Chagas, Doença de |
| status_str | publishedVersion |
| title | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| title_full | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| title_fullStr | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| title_full_unstemmed | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| title_short | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| title_sort | Dendritic cells : a double-edged sword in immune responses during chagas disease |
| topic | Células dendríticas Antígenos Trypanosoma cruzi Chagas, Doença de |
| url | http://repositorio.unb.br/handle/10482/23883 https://dx.doi.org/10.3389/fmicb.2016.01076 |