Melatonin prevents age-related hearing loss in the murin experimental model
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| Publication Date: | 2022 |
| Other Authors: | , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da UnB |
| Download full: | https://repositorio.unb.br/handle/10482/45209 https://doi.org/10.1016/j.bjorl.2022.06.002 https://orcid.org/0000-0002-8113-7222 https://orcid.org/0000-0001-7853-3016 https://orcid.org/0000-0003-4494-3353 https://orcid.org/0000-0002-2777-9494 https://orcid.org/0000-0001-5132-8370 https://orcid.org/0000-0001-7677-772X https://orcid.org/0000-0001-7611-1303 |
Summary: | Objective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period. Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 L of 10 mg of melatonin/kg/day orally for a 12-month period. After de experiment the animals were sacrificed into a 40% concentration of CO2 chamber, and the blades were morphological and morphometrically analyzed. Results: The melatonin group revealed a higher median density of viable cells (45 ± 10.28 cells/100 m2, 31---73, vs. 32 ± 7.47 cells/100 m2, 25---48). The median area of stria vascularis was 55.0 ± 12.27 cells/100 m2 (38---80) in the control, and 59.0 ± 16.13 cells/100 m2 (40---134) in the melatonin group. The morphometric analysis of the spiral ligament reveals a higher median of total viable neurons in the melatonin (41 ± 7.47 cells/100 m2, 27---60) than in the control group (31 ± 5.68 cells/100 m2, 21---44). Conclusion: Although melatonin is a potent antioxidant, it does not completely neutralize the occurrence of presbycusis; however, it may delay the onset of this condition. |
| _version_ | 1871442554764918784 |
|---|---|
| author | Serra, Lucieny Silva Martins |
| author2 | Araújo, Juliana Gusmão de Novanta, Gabriela Lauand, Lucas Silva, Eduardo Magalhães da Kückelhaus, Selma Aparecida Souza Sampaio, André Luiz Lopes |
| author2_role | author author author author author author |
| author_browse | Araújo, Juliana Gusmão de Kückelhaus, Selma Aparecida Souza Lauand, Lucas Novanta, Gabriela Sampaio, André Luiz Lopes Serra, Lucieny Silva Martins Silva, Eduardo Magalhães da |
| author_facet | Serra, Lucieny Silva Martins Araújo, Juliana Gusmão de Novanta, Gabriela Lauand, Lucas Silva, Eduardo Magalhães da Kückelhaus, Selma Aparecida Souza Sampaio, André Luiz Lopes |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/45209/1/ARTIGO_MelatoninPreventsAge.pdf http://repositorio.unb.br/bitstream/10482/45209/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.author.fl_str_mv | Serra, Lucieny Silva Martins Araújo, Juliana Gusmão de Novanta, Gabriela Lauand, Lucas Silva, Eduardo Magalhães da Kückelhaus, Selma Aparecida Souza Sampaio, André Luiz Lopes |
| dc.contributor.email.pt_BR.fl_str_mv | mailto:lucienymserra@gmail.com mailto:andremarjy@uol.com.br |
| dc.date.accessioned.fl_str_mv | 2022-11-22T21:38:05Z |
| dc.date.available.fl_str_mv | 2022-11-22T21:38:05Z |
| dc.date.issued.fl_str_mv | 2022-06-14 |
| dc.identifier.citation.fl_str_mv | SERRA, Lucieny Silva Martins et. al. Melatonin prevents age-related hearing loss in the murin experimental model. Brazilian Journal of Otorhinolaryngology, Campinas, 2022. DOI 10.1016/j.bjorl.2022.06.002. Disponível em: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.1016/j.bjorl.2022.06.002 |
| dc.identifier.orcid.pt_BR.fl_str_mv | https://orcid.org/0000-0002-8113-7222 https://orcid.org/0000-0001-7853-3016 https://orcid.org/0000-0003-4494-3353 https://orcid.org/0000-0002-2777-9494 https://orcid.org/0000-0001-5132-8370 https://orcid.org/0000-0001-7677-772X https://orcid.org/0000-0001-7611-1303 |
| dc.identifier.uri.fl_str_mv | https://repositorio.unb.br/handle/10482/45209 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.pt_BR.fl_str_mv | Melatonina Perda auditiva Células ciliadas externas |
| dc.title.pt_BR.fl_str_mv | Melatonin prevents age-related hearing loss in the murin experimental model |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Objective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period. Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 L of 10 mg of melatonin/kg/day orally for a 12-month period. After de experiment the animals were sacrificed into a 40% concentration of CO2 chamber, and the blades were morphological and morphometrically analyzed. Results: The melatonin group revealed a higher median density of viable cells (45 ± 10.28 cells/100 m2, 31---73, vs. 32 ± 7.47 cells/100 m2, 25---48). The median area of stria vascularis was 55.0 ± 12.27 cells/100 m2 (38---80) in the control, and 59.0 ± 16.13 cells/100 m2 (40---134) in the melatonin group. The morphometric analysis of the spiral ligament reveals a higher median of total viable neurons in the melatonin (41 ± 7.47 cells/100 m2, 27---60) than in the control group (31 ± 5.68 cells/100 m2, 21---44). Conclusion: Although melatonin is a potent antioxidant, it does not completely neutralize the occurrence of presbycusis; however, it may delay the onset of this condition. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_dbe909b4e36c32e7dc06ac1ad8eadeae |
| identifier_str_mv | SERRA, Lucieny Silva Martins et. al. Melatonin prevents age-related hearing loss in the murin experimental model. Brazilian Journal of Otorhinolaryngology, Campinas, 2022. DOI 10.1016/j.bjorl.2022.06.002. Disponível em: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/45209 |
| publishDate | 2022 |
| publishDateSort | 2022 |
| publisher.none.fl_str_mv | Elsevier |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Serra, Lucieny Silva MartinsAraújo, Juliana Gusmão deNovanta, GabrielaLauand, LucasSilva, Eduardo Magalhães daKückelhaus, Selma Aparecida SouzaSampaio, André Luiz Lopesmailto:lucienymserra@gmail.commailto:andremarjy@uol.com.br2022-11-22T21:38:05Z2022-11-22T21:38:05Z2022-06-14SERRA, Lucieny Silva Martins et. al. Melatonin prevents age-related hearing loss in the murin experimental model. Brazilian Journal of Otorhinolaryngology, Campinas, 2022. DOI 10.1016/j.bjorl.2022.06.002. Disponível em: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022.https://repositorio.unb.br/handle/10482/45209https://doi.org/10.1016/j.bjorl.2022.06.002https://orcid.org/0000-0002-8113-7222https://orcid.org/0000-0001-7853-3016https://orcid.org/0000-0003-4494-3353https://orcid.org/0000-0002-2777-9494https://orcid.org/0000-0001-5132-8370https://orcid.org/0000-0001-7677-772Xhttps://orcid.org/0000-0001-7611-1303Elsevier1808-8694/© 2022 Associacão Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Fonte: https://www.sciencedirect.com/science/article/pii/S1808869422000829?via%3Dihub. Acesso em: 22 nov. 2022.info:eu-repo/semantics/openAccessMelatonin prevents age-related hearing loss in the murin experimental modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMelatoninaPerda auditivaCélulas ciliadas externasObjective: The present study aimed to perform a morphological and morphometric analysis of cochlear structures of C57BL/6J mice receiving oral melatonin for a 12-month period. Methods: 32 male C57BL/6J were divided into control and melatonin groups. Control received saline and ethanol solution and melatonin group, 50 L of 10 mg of melatonin/kg/day orally for a 12-month period. After de experiment the animals were sacrificed into a 40% concentration of CO2 chamber, and the blades were morphological and morphometrically analyzed. Results: The melatonin group revealed a higher median density of viable cells (45 ± 10.28 cells/100 m2, 31---73, vs. 32 ± 7.47 cells/100 m2, 25---48). The median area of stria vascularis was 55.0 ± 12.27 cells/100 m2 (38---80) in the control, and 59.0 ± 16.13 cells/100 m2 (40---134) in the melatonin group. The morphometric analysis of the spiral ligament reveals a higher median of total viable neurons in the melatonin (41 ± 7.47 cells/100 m2, 27---60) than in the control group (31 ± 5.68 cells/100 m2, 21---44). Conclusion: Although melatonin is a potent antioxidant, it does not completely neutralize the occurrence of presbycusis; however, it may delay the onset of this condition.Faculdade de Medicina (FM)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_MelatoninPreventsAge.pdfARTIGO_MelatoninPreventsAge.pdfapplication/pdf1083453http://repositorio.unb.br/bitstream/10482/45209/1/ARTIGO_MelatoninPreventsAge.pdfd8b9b5dcd37bac361ac69adaa0fc7ec2MD51open accessLICENSElicense.txtlicense.txttext/plain163http://repositorio.unb.br/bitstream/10482/45209/2/license.txtba54f8d1c5f5ec8df897ad678916c701MD52open access10482/452092025-01-15 16:19:32.412open accessoai:repositorio.unb.br:10482/45209U3VibWlzc8OjbyBlZmV0aXZhZGEgcG9yIGludGVncmFudGUgZGEgZXF1aXBlIGRvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIFVuQiBkZSBhY29yZG8gY29tIGxpY2Vuw6dhIGNvbmNlZGlkYSBwZWxvIGF1dG9yIGUvb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzLg==Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-01-15T19:19:32Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Melatonin prevents age-related hearing loss in the murin experimental model Serra, Lucieny Silva Martins Melatonina Perda auditiva Células ciliadas externas |
| status_str | publishedVersion |
| title | Melatonin prevents age-related hearing loss in the murin experimental model |
| title_full | Melatonin prevents age-related hearing loss in the murin experimental model |
| title_fullStr | Melatonin prevents age-related hearing loss in the murin experimental model |
| title_full_unstemmed | Melatonin prevents age-related hearing loss in the murin experimental model |
| title_short | Melatonin prevents age-related hearing loss in the murin experimental model |
| title_sort | Melatonin prevents age-related hearing loss in the murin experimental model |
| topic | Melatonina Perda auditiva Células ciliadas externas |
| url | https://repositorio.unb.br/handle/10482/45209 https://doi.org/10.1016/j.bjorl.2022.06.002 https://orcid.org/0000-0002-8113-7222 https://orcid.org/0000-0001-7853-3016 https://orcid.org/0000-0003-4494-3353 https://orcid.org/0000-0002-2777-9494 https://orcid.org/0000-0001-5132-8370 https://orcid.org/0000-0001-7677-772X https://orcid.org/0000-0001-7611-1303 |