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Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice

Đã lưu trong:
Chi tiết về thư mục
Tác giả chính: Santarem, Ana Angélica Amorim
Ngày xuất bản: 2014
Tác giả khác: Greggianin, Gabriel Frizon, Debastiani, Rafaela Garcia, Ribeiro, Jefferson Bruno Pereira, Polli, Démerson André, Sampaio, Raimunda Nonata Ribeiro
Định dạng: Article
Ngôn ngữ: eng
Nguồn: Repositório Institucional da UnB
Download full: http://repositorio.unb.br/handle/10482/29126
https://dx.doi.org/10.1590/0037-8682-0202-2013
Tóm tắt: Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection.

Những quyển sách tương tự: Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice

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