Effectiveness of miltefosine-pentoxifylline compared to miltefosine in the treatment of cutaneous leishmaniasis in C57Bl / 6 mice
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| Autore principale: | |
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| Data di pubblicazione: | 2014 |
| Altri autori: | , , , , |
| Natura: | Article |
| Lingua: | eng |
| Fonte: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/29126 https://dx.doi.org/10.1590/0037-8682-0202-2013 |
Riassunto: | Introduction The treatment of leishmaniasis ischallenging, given the difficulties in drug administration and resistance. Therefore, we chose to test the efficacy of miltefosine combined with pentoxifylline. Methods Twenty-seven isogenic C57Bl/6 mice were infected with Leishmania (Leishmania) amazonensis, and equally divided into three groups: miltefosine (200mg/kg/day), miltefosine (200mg/kg/day) with pentoxifylline (8mg/kg/day), and untreated. Response to treatment was evaluated using paw diameter and parasitological criteria. Results The number of viable Leishmania reduced significantly within the miltefosine-pentoxifylline group (p < 0.05). Conclusions There is hope that a viable treatment exists for Leishmania infection. |