BDNF genetic variant and its genotypic fluctuation in major depressive disorder
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| Datum vydání: | 2021 |
| Další autoři: | , , , , |
| Médium: | Article |
| Jazyk: | por |
| Zdroj: | Repositório Institucional da UnB |
| Download full: | http://repositorio2.unb.br/jspui/handle/10482/48568 https://doi.org/10.1155/2021/7117613 |
Shrnutí: | Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients. |
| _version_ | 1871442487060463616 |
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| author | Fratelli, Caroline Ferreira |
| author2 | Siqueira, Jhon Willatan Gontijo, Bruna Rodrigues Santos, Maurício de Lima Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da |
| author2_role | author author author author author |
| author_browse | Fratelli, Caroline Ferreira Gontijo, Bruna Rodrigues Santos, Maurício de Lima Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da Siqueira, Jhon Willatan |
| author_facet | Fratelli, Caroline Ferreira Siqueira, Jhon Willatan Gontijo, Bruna Rodrigues Santos, Maurício de Lima Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da |
| author_role | author |
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| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/48568/1/ARTIGO_BDNFGeneticVariant.pdf http://repositorio.unb.br/bitstream/10482/48568/2/license.txt |
| collection | Repositório Institucional da UnB |
| dc.contributor.affiliation.pt_BR.fl_str_mv | University of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies Program University of Brasilia, Faculty of Ceilândia University of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies Program University of Brasilia, Faculty of Ceilândia University of Brasilia, Faculty of Ceilândia University of Brasilia, Faculty of Ceilândia |
| dc.contributor.author.fl_str_mv | Fratelli, Caroline Ferreira Siqueira, Jhon Willatan Gontijo, Bruna Rodrigues Santos, Maurício de Lima Silva, Calliandra Maria de Souza Silva, Izabel Cristina Rodrigues da |
| dc.contributor.orcid.none.fl_str_mv | https://orcid.org/0000-0002-6836-3583 |
| dc.date.accessioned.fl_str_mv | 2024-07-05T15:16:05Z |
| dc.date.available.fl_str_mv | 2024-07-05T15:16:05Z |
| dc.date.issued.fl_str_mv | 2021-11-10 |
| dc.identifier.citation.fl_str_mv | FRATELLI, Caroline Ferreira et al. BDNF genetic variant and its genotypic fluctuation in major depressive disorder. Behavioural Neurology, v. 2021, Article ID 7117613, 16 p., 2021. DOI: https://doi.org/10.1155/2021/7117613. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/7117613. Acesso em: 05 jul. 2024. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.1155/2021/7117613 |
| dc.identifier.uri.fl_str_mv | http://repositorio2.unb.br/jspui/handle/10482/48568 |
| dc.language.iso.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Wiley Open Access |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.none.fl_str_mv | Polimorfismo (Genética) Depressão mental |
| dc.title.pt_BR.fl_str_mv | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_c38fa7b34ad55fbd271e9bfd7d9ca072 |
| identifier_str_mv | FRATELLI, Caroline Ferreira et al. BDNF genetic variant and its genotypic fluctuation in major depressive disorder. Behavioural Neurology, v. 2021, Article ID 7117613, 16 p., 2021. DOI: https://doi.org/10.1155/2021/7117613. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/7117613. Acesso em: 05 jul. 2024. |
| instacron_str | UNB |
| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | por |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/48568 |
| publishDate | 2021 |
| publishDateSort | 2021 |
| publisher.none.fl_str_mv | Wiley Open Access |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| repository_id_str | |
| spelling | Fratelli, Caroline FerreiraSiqueira, Jhon WillatanGontijo, Bruna RodriguesSantos, Maurício de LimaSilva, Calliandra Maria de SouzaSilva, Izabel Cristina Rodrigues daUniversity of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies ProgramUniversity of Brasilia, Faculty of CeilândiaUniversity of Brasilia, Faculty of Ceilândia, Health Sciences and Technologies ProgramUniversity of Brasilia, Faculty of CeilândiaUniversity of Brasilia, Faculty of CeilândiaUniversity of Brasilia, Faculty of Ceilândiahttps://orcid.org/0000-0002-6836-35832024-07-05T15:16:05Z2024-07-05T15:16:05Z2021-11-10FRATELLI, Caroline Ferreira et al. BDNF genetic variant and its genotypic fluctuation in major depressive disorder. Behavioural Neurology, v. 2021, Article ID 7117613, 16 p., 2021. DOI: https://doi.org/10.1155/2021/7117613. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2021/7117613. Acesso em: 05 jul. 2024.http://repositorio2.unb.br/jspui/handle/10482/48568https://doi.org/10.1155/2021/7117613porWiley Open Access© 2021 Caroline Ferreira Fratelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/openAccessBDNF genetic variant and its genotypic fluctuation in major depressive disorderinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlePolimorfismo (Genética)Depressão mentalMajor depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both were also found in MDD, whether related to the disease’s development or other factors. Nevertheless, despite these findings, disagreements between several studies are seen. For this reason, further BDNF Val66Met genetic variant studies should not only bridge the gap in the knowledge of this polymorphism’s role in MDD’s different facets but also analyze the genotypic and phenotypic heterogeneity in different populations to help provide a better quality of life for patients.Faculdade de Ciências e Tecnologias em Saúde (FCTS) – Campus UnB CeilândiaPrograma de Pós-Graduação em Ciências e Tecnologias em Saúdereponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_BDNFGeneticVariant.pdfARTIGO_BDNFGeneticVariant.pdfapplication/pdf611037http://repositorio.unb.br/bitstream/10482/48568/1/ARTIGO_BDNFGeneticVariant.pdfecf5e95a0b939957b3124b3dfa87fe86MD51open accessLICENSElicense.txtlicense.txttext/plain102http://repositorio.unb.br/bitstream/10482/48568/2/license.txtaed4704d04bb260d4decd80db311aaa5MD52open access10482/485682025-02-11 16:10:53.651open accessoai:repositorio.unb.br:10482/48568U3VibWlzc8OjbyBlZmV0aXZhZGEgZGUgYWNvcmRvIGNvbSBsaWNlbsOnYSBjb25jZWRpZGEgcGVsbyBhdXRvciBlL291IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcy4KRepositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2025-02-11T19:10:53Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | BDNF genetic variant and its genotypic fluctuation in major depressive disorder Fratelli, Caroline Ferreira Polimorfismo (Genética) Depressão mental |
| status_str | publishedVersion |
| title | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| title_full | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| title_fullStr | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| title_full_unstemmed | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| title_short | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| title_sort | BDNF genetic variant and its genotypic fluctuation in major depressive disorder |
| topic | Polimorfismo (Genética) Depressão mental |
| url | http://repositorio2.unb.br/jspui/handle/10482/48568 https://doi.org/10.1155/2021/7117613 |