Polimorfismo TP53 Arg72Pro e sua relação com o transtorno depressivo maior

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Bibliographic Details
Main Author:	Rodrigues, Guilherme Oliveira
Publication Date:	2026
Other Authors:	Bonasser, Larissa Sousa Silva, Santos, Mauricio de Lima, Silva, Calliandra Maria de Souza, Fratelli, Caroline Ferreira, Silva, Izabel Cristina Rodrigues da
Format:	Article
Language:	por
Source:	Repositório Institucional da UnB
Download full:	http://repositorio.unb.br/handle/10482/55258 https://doi.org/10.53660/CLM-3726-23P17 https://orcid.org/0009-0009-5216-1045 https://orcid.org/0000-0002-7812-8026 https://orcid.org/0000-0002-3716-7221 https://orcid.org/0000-0002-9064-0735 https://orcid.org/0000-0002-0511-9452 https://orcid.org/0000-0002-6836-3583
Summary:	This study investigates the association between theTP53 Arg72Propolymorphism and major depressive disorder (MDD) using a case-control approach. The study sample comprised 97 individuals: 16 in the case group diagnosed with MDD and 81 in the control group. Genotypingwas conducted using the PCR-RFLP technique, with the genotypic frequencies calculated by direct counting and statistical significance at 5% (P<0.05). Results indicated that theTP53 Arg72Propolymorphism'sProallele was significantly more frequent in the MDD case group. These findings suggest that the Proallele is associated with an increased risk of developing major depressive disorder.

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