Development of transferosomes for topical ocular drug delivery of curcumin
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| Autor Principal: | |
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| Data de Publicación: | 2024 |
| Outros autores: | , , , , , , |
| Formato: | Article |
| Idioma: | eng |
| Fonte: | Repositório Institucional da UnB |
| Download full: | https://doi.org/10.1016/j.ejpb.2024.114535 http://repositorio.unb.br/handle/10482/54680 https://orcid.org/0000-0001-6481-2364 https://orcid.org/0000-0001-8888-2340 https://orcid.org/0000-0001-5997-5994 https://orcid.org/0000-0002-3831-3833 |
Summary: | Background Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have previously been used to enhance gradient driven penetration through the skin. This study aimed to evaluate the potential of TFS for topical ocular drug delivery and to compare their penetration enhancing properties in different ocular tissues. Methods Curcumin-loaded TFS were prepared using Tween 80 as the edge activator. Drug release and precorneal retention of the TFS were evaluated in vitro, while their ocular biocompatibility and bioavailability were evaluated ex vivo using a curcumin solution in medium chain triglycerides as the oily control. Results The TFS had a narrow size distribution with a particle size less than 150 nm and an entrapment efficiency greater than 99.96 %. Burst release from the TFS was minimal and the formulation showed good corneal biocompatibility. Moreover, enhanced corneal and conjunctival drug penetration with significantly greater and deeper drug delivery was observed with TFS. Conclusion TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues. |
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