Development of transferosomes for topical ocular drug delivery of curcumin
Gorde:
| Egile nagusia: | |
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| Argitaratze data: | 2024 |
| Beste egile batzuk: | , , , , , , |
| Formatua: | Article |
| Hizkuntza: | eng |
| Baliabidea: | Repositório Institucional da UnB |
| Download full: | https://doi.org/10.1016/j.ejpb.2024.114535 http://repositorio.unb.br/handle/10482/54680 https://orcid.org/0000-0001-6481-2364 https://orcid.org/0000-0001-8888-2340 https://orcid.org/0000-0001-5997-5994 https://orcid.org/0000-0002-3831-3833 |
Gaia: | Background Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have previously been used to enhance gradient driven penetration through the skin. This study aimed to evaluate the potential of TFS for topical ocular drug delivery and to compare their penetration enhancing properties in different ocular tissues. Methods Curcumin-loaded TFS were prepared using Tween 80 as the edge activator. Drug release and precorneal retention of the TFS were evaluated in vitro, while their ocular biocompatibility and bioavailability were evaluated ex vivo using a curcumin solution in medium chain triglycerides as the oily control. Results The TFS had a narrow size distribution with a particle size less than 150 nm and an entrapment efficiency greater than 99.96 %. Burst release from the TFS was minimal and the formulation showed good corneal biocompatibility. Moreover, enhanced corneal and conjunctival drug penetration with significantly greater and deeper drug delivery was observed with TFS. Conclusion TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues. |
| _version_ | 1871442352510337024 |
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| author | Barbalho, Geisa Nascimento |
| author2 | Brugger, Stefan Raab, Christian Lechner, Jara Sophie Gratieri, Taís Keck, Cornelia M. Rupenthal, Ilva D. Agarwal, Priyanka |
| author2_role | author author author author author author author |
| author_browse | Agarwal, Priyanka Barbalho, Geisa Nascimento Brugger, Stefan Gratieri, Taís Keck, Cornelia M. Lechner, Jara Sophie Raab, Christian Rupenthal, Ilva D. |
| author_facet | Barbalho, Geisa Nascimento Brugger, Stefan Raab, Christian Lechner, Jara Sophie Gratieri, Taís Keck, Cornelia M. Rupenthal, Ilva D. Agarwal, Priyanka |
| author_role | author |
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| bitstream.checksumAlgorithm.fl_str_mv | MD5 |
| bitstream.url.fl_str_mv | http://repositorio.unb.br/bitstream/10482/54680/1/ARTIGO_DevelopmentTransferosomesTopical.pdf |
| collection | Repositório Institucional da UnB |
| dc.contributor.affiliation.none.fl_str_mv | The University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics Unit University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) The University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics Unit Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) Philipps-Universität Marburg, Department of Pharmaceutics and Biopharmaceutics University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC) |
| dc.contributor.author.fl_str_mv | Barbalho, Geisa Nascimento Brugger, Stefan Raab, Christian Lechner, Jara Sophie Gratieri, Taís Keck, Cornelia M. Rupenthal, Ilva D. Agarwal, Priyanka |
| dc.date.accessioned.fl_str_mv | 2026-06-09T22:34:58Z |
| dc.date.available.fl_str_mv | 2026-06-09T22:34:58Z |
| dc.date.issued.fl_str_mv | 2024 |
| dc.identifier.citation.fl_str_mv | BARBALHO, Geisa Nascimento; BRUGGER, Stefan; RAAB, Christian; LECHNER, Jara-Sophie; GRATIERI, Taís; KECK, Cornelia M.; RUPENTHAL, Ilva D.; AGARWAL, Priyanka. Development of transferosomes for topical ocular drug delivery of curcumin. European Journal of Pharmaceutics and Biopharmaceutics, [S. l.], v. 205, 114535, 2024. DOI: https://doi.org/10.1016/j.ejpb.2024.114535. Disponível em: https://www.sciencedirect.com/science/article/pii/S0939641124003618?via%3Dihub. Acesso em: 10 jun. 2026. |
| dc.identifier.doi.pt_BR.fl_str_mv | https://doi.org/10.1016/j.ejpb.2024.114535 |
| dc.identifier.orcid.pt_BR.fl_str_mv | https://orcid.org/0000-0001-6481-2364 https://orcid.org/0000-0001-8888-2340 https://orcid.org/0000-0001-5997-5994 https://orcid.org/0000-0002-3831-3833 |
| dc.identifier.uri.fl_str_mv | https://doi.org/10.1016/j.ejpb.2024.114535 http://repositorio.unb.br/handle/10482/54680 |
| dc.language.iso.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier BV |
| dc.rights.driver.fl_str_mv | info:eu-repo/semantics/openAccess |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
| dc.subject.keyword.none.fl_str_mv | Medicamentos oftalmológicos - administração Lipossomas Transferossomos Curcumina |
| dc.title.pt_BR.fl_str_mv | Development of transferosomes for topical ocular drug delivery of curcumin |
| dc.type.driver.fl_str_mv | info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv | info:eu-repo/semantics/publishedVersion |
| description | Background Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have previously been used to enhance gradient driven penetration through the skin. This study aimed to evaluate the potential of TFS for topical ocular drug delivery and to compare their penetration enhancing properties in different ocular tissues. Methods Curcumin-loaded TFS were prepared using Tween 80 as the edge activator. Drug release and precorneal retention of the TFS were evaluated in vitro, while their ocular biocompatibility and bioavailability were evaluated ex vivo using a curcumin solution in medium chain triglycerides as the oily control. Results The TFS had a narrow size distribution with a particle size less than 150 nm and an entrapment efficiency greater than 99.96 %. Burst release from the TFS was minimal and the formulation showed good corneal biocompatibility. Moreover, enhanced corneal and conjunctival drug penetration with significantly greater and deeper drug delivery was observed with TFS. Conclusion TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues. |
| eu_rights_str_mv | openAccess |
| format | article |
| id | UNB_6deddec58cf0761e21aef02f55da497a |
| identifier_str_mv | BARBALHO, Geisa Nascimento; BRUGGER, Stefan; RAAB, Christian; LECHNER, Jara-Sophie; GRATIERI, Taís; KECK, Cornelia M.; RUPENTHAL, Ilva D.; AGARWAL, Priyanka. Development of transferosomes for topical ocular drug delivery of curcumin. European Journal of Pharmaceutics and Biopharmaceutics, [S. l.], v. 205, 114535, 2024. DOI: https://doi.org/10.1016/j.ejpb.2024.114535. Disponível em: https://www.sciencedirect.com/science/article/pii/S0939641124003618?via%3Dihub. Acesso em: 10 jun. 2026. |
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| institution | UNB |
| instname_str | Universidade de Brasília (UnB) |
| language | eng |
| network_acronym_str | UNB |
| network_name_str | Repositório Institucional da UnB |
| oai_identifier_str | oai:repositorio.unb.br:10482/54680 |
| publishDate | 2024 |
| publishDateSort | 2024 |
| publisher.none.fl_str_mv | Elsevier BV |
| reponame_str | Repositório Institucional da UnB |
| repository.mail.fl_str_mv | repositorio@unb.br |
| repository.name.fl_str_mv | Repositório Institucional da UnB - Universidade de Brasília (UnB) |
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| spelling | Barbalho, Geisa NascimentoBrugger, StefanRaab, ChristianLechner, Jara SophieGratieri, TaísKeck, Cornelia M.Rupenthal, Ilva D.Agarwal, PriyankaThe University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics UnitUniversity of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC)The University of Auckland, Faculty of Medical and Health Sciences, Department of Ophthalmology, Aotearoa-New Zealand National Eye Centre, Buchanan Ocular Therapeutics UnitPhilipps-Universität Marburg, Department of Pharmaceutics and BiopharmaceuticsPhilipps-Universität Marburg, Department of Pharmaceutics and BiopharmaceuticsUniversity of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC)Philipps-Universität Marburg, Department of Pharmaceutics and BiopharmaceuticsUniversity of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC)University of Brasilia, Laboratory of Food, Drugs and Cosmetics (LTMAC)2026-06-09T22:34:58Z2026-06-09T22:34:58Z2024BARBALHO, Geisa Nascimento; BRUGGER, Stefan; RAAB, Christian; LECHNER, Jara-Sophie; GRATIERI, Taís; KECK, Cornelia M.; RUPENTHAL, Ilva D.; AGARWAL, Priyanka. Development of transferosomes for topical ocular drug delivery of curcumin. European Journal of Pharmaceutics and Biopharmaceutics, [S. l.], v. 205, 114535, 2024. DOI: https://doi.org/10.1016/j.ejpb.2024.114535. Disponível em: https://www.sciencedirect.com/science/article/pii/S0939641124003618?via%3Dihub. Acesso em: 10 jun. 2026.https://doi.org/10.1016/j.ejpb.2024.114535http://repositorio.unb.br/handle/10482/54680https://doi.org/10.1016/j.ejpb.2024.114535https://orcid.org/0000-0001-6481-2364https://orcid.org/0000-0001-8888-2340https://orcid.org/0000-0001-5997-5994https://orcid.org/0000-0002-3831-3833engElsevier BVThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ ).info:eu-repo/semantics/openAccessDevelopment of transferosomes for topical ocular drug delivery of curcumininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMedicamentos oftalmológicos - administraçãoLipossomasTransferossomosCurcuminaBackground Transferosomes (TFS) are ultra-deformable elastic bilayer vesicles that have previously been used to enhance gradient driven penetration through the skin. This study aimed to evaluate the potential of TFS for topical ocular drug delivery and to compare their penetration enhancing properties in different ocular tissues. Methods Curcumin-loaded TFS were prepared using Tween 80 as the edge activator. Drug release and precorneal retention of the TFS were evaluated in vitro, while their ocular biocompatibility and bioavailability were evaluated ex vivo using a curcumin solution in medium chain triglycerides as the oily control. Results The TFS had a narrow size distribution with a particle size less than 150 nm and an entrapment efficiency greater than 99.96 %. Burst release from the TFS was minimal and the formulation showed good corneal biocompatibility. Moreover, enhanced corneal and conjunctival drug penetration with significantly greater and deeper drug delivery was observed with TFS. Conclusion TFS offer a promising platform for ocular delivery of hydrophobic drugs. This study, for the first time, elucidates the effect of tissue morphology and osmotic gradients on drug penetration in different ocular tissues.Faculdade de Ciências da Saúde (FS)Departamento de Farmácia (FS FAR)Programa de Pós-Graduação em Ciências Farmacêuticasreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_DevelopmentTransferosomesTopical.pdfARTIGO_DevelopmentTransferosomesTopical.pdfapplication/pdf5978561http://repositorio.unb.br/bitstream/10482/54680/1/ARTIGO_DevelopmentTransferosomesTopical.pdfc9542ce786be74e280e5b0536354716eMD51open access10482/546802026-06-11 12:37:55.978open accessoai:repositorio.unb.br:10482/54680Repositório InstitucionalPUBhttps://repositorio.unb.br/oai/requestrepositorio@unb.bropendoar:2026-06-11T15:37:55Repositório Institucional da UnB - Universidade de Brasília (UnB) |
| spellingShingle | Development of transferosomes for topical ocular drug delivery of curcumin Barbalho, Geisa Nascimento Medicamentos oftalmológicos - administração Lipossomas Transferossomos Curcumina |
| status_str | publishedVersion |
| title | Development of transferosomes for topical ocular drug delivery of curcumin |
| title_full | Development of transferosomes for topical ocular drug delivery of curcumin |
| title_fullStr | Development of transferosomes for topical ocular drug delivery of curcumin |
| title_full_unstemmed | Development of transferosomes for topical ocular drug delivery of curcumin |
| title_short | Development of transferosomes for topical ocular drug delivery of curcumin |
| title_sort | Development of transferosomes for topical ocular drug delivery of curcumin |
| topic | Medicamentos oftalmológicos - administração Lipossomas Transferossomos Curcumina |
| url | https://doi.org/10.1016/j.ejpb.2024.114535 http://repositorio.unb.br/handle/10482/54680 https://orcid.org/0000-0001-6481-2364 https://orcid.org/0000-0001-8888-2340 https://orcid.org/0000-0001-5997-5994 https://orcid.org/0000-0002-3831-3833 |