Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
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| 主要作者: | |
|---|---|
| Publication Date: | 2019 |
| 其他作者: | , , , , , , |
| 格式: | Article |
| 语言: | eng |
| Source: | Repositório Institucional da UnB |
| Download full: | https://repositorio.unb.br/handle/10482/36247 https://doi.org/10.1590/0037-8682-0001-2018 http://orcid.org/0000-0002-4181-142X |
总结: | INTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. CONCLUSIONS: These findings highlight the role of host stress in the virulence of S. epidermidis. |
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