The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
Tallennettuna:
| Päätekijä: | |
|---|---|
| Julkaisupäivä: | 2018 |
| Muut tekijät: | , , , , |
| Aineistotyyppi: | Article |
| Kieli: | eng |
| Lähde: | Repositório Institucional da UnB |
| Download full: | http://repositorio.unb.br/handle/10482/34070 https://doi.org/10.1155/2018/9128754 |
Yhteenveto: | Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer. |
Samankaltaisia teoksia: The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review
- The impact of NOS3 gene polymorphism on papillary thyroid cancer susceptibility in patients undergoing radioiodine therapy
- BAX gene (−248 G > A) polymorphism in a sample of patients diagnosed with thyroid cancer in the Federal District, Brazil
- Rearrangements in thyroid hormone receptor charge clusters that stabilize bound 3,5',5-triiodo-l-thyronine and inhibit homodimer formation
- Polimorfismo genético dos genes P53, IL6 E TNFA em pacientes portadores do câncer papilífero da tireoide submetidos a iodoterapia em uma amostra do Distrito Federal
- Structural basis of GC-1 selectivity for thyroid hormone receptor isoforms
- Thyroid hormone response element organization dictates the composition of active receptor