The role of the NIS (SLC5A5) gene in Papillary thyroid cancer : a systematic review

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Bibliographic Details
Main Author:	Morais, Rafael Martins de
Publication Date:	2018
Other Authors:	Barra Sobrinho, Alaor, Silva, Calliandra Maria de Souza, Oliveira, Jamila Reis de, Silva, Izabel Cristina Rodrigues da, Nóbrega, Otávio de Tolêdo
Format:	Article
Language:	eng
Source:	Repositório Institucional da UnB
Download full:	http://repositorio.unb.br/handle/10482/34070 https://doi.org/10.1155/2018/9128754
Summary:	Papillary thyroid cancer (PTC) is the most common thyroid malignancy. Genetic and epigenetic alterations play a decisive role in the onset of several human neoplasms. Mutations and polymorphisms are two frequent genetic alterations. Located on chromosome 19 (19p13.11), the NIS SLC5A5 (solute carrier family 5 member 5) gene encodes a highly specialized and efficient 80–90 kDa transmembrane glycoprotein that mediates active transport of iodide from the bloodstream into the follicular cells. Given the highly significant role of NIS in the physiology and the cancer pathogenesis process, this paper’s objective is to provide a comprehensive assessment of the associations between NIS gene and protein with papillary thyroid cancer.

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