Texto sistemático crítico evidenciando a evolução das pesquisas realizadas e o seu contexto cronológico na área de produtos naturais e de síntese orgânica

• Autor(a) principal: Laurentiz, Rosangela da Silva de
• Data de Publicação: 2022
• Tipo de documento: Outros
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://hdl.handle.net/11449/234694
• topic: Natural products; Organic synthesis; Lignans; Tetronic acid; Quinolines; Produtos naturais; Síntese orgânicas; Lignanas; Ácido tetrônico; Quinolinas

Plants are an inexhaustible source of organic compounds with the most varied chemical structures and biological properties. These compounds are called secondary metabolites and are involved in the secondary metabolism of plants being produced in response to external agents such as predators, parasites, other plants, environmental factors and soil (nutrients). The diversity of biological properties that they present in plants calls attention to a possible application in the control of some diseases that also affect humans and animals. Among the main classes of secondary metabolites produced by plants, lignans became the target of study by several research groups after the discovery of the anticancer properties of podophyllotoxin. Since then, other lignans have been isolated, identified and evaluated for their biological properties. Such properties are strictly related to the chemical skeletons of each subclass, stereochemistry, nature and position of the substituents. Due to the biological properties and the synthetic challenge related to asymmetric centers, numerous methodologies for the synthesis of lignans and derivatives have been proposed in order to obtain molecules that can be used as targets for the development of new drugs. With scientific advances, molecular modeling tools combined with in vitro assays have facilitated the planning of synthetic targets, guiding the synthesis to obtain compounds with greater probability of being active in vivo against the biological target evaluated in silico. In the course of my research, I have worked with plant extracts, natural lignans, total synthesis of lignans, partial synthesis of derivatives of natural lignans, synthesis of heterocyclic analogues of lignans and the biological evaluation of these compounds. For some biological targets, molecular modeling has been used as a guide to define the type of compound to be synthesized and evaluated in vivo. I have used the fruits of Piper cubeba to obtain the cubebin lignan which has been evaluated in several biological assays and used as a starting material for the synthesis of derivatives and other lignans. From this lignan I published many of my scientific articles and even today this compound continues to be a source of inspiration for two other projects that I develop. Lignans have also been the inspiration for the synthesis of heterocyclic analogues that have interesting biological and luminescent properties. In this text, I comment on the scientific articles linked to both the area of natural products and the area of synthesis that I have published in recent years with the aim of highlighting the evolution of the research carried out and its chronological context.