A Brazilian multicentre study evaluating pregnancies induced by cabergoline in patients harboring prolactinomas

• Main Author: Sant’ Anna, B. G.
• Publication Date: 2020
• Other Authors: Musolino, N. R.C., Gadelha, M. R., Marques, C., Castro, M., Elias, P. C.L., Vilar, L., Lyra, R., Martins, M. R.A., Quidute, A. R.P., Abucham, J., Nazato, D., Garmes, H. M., Fontana, M. L.C., Boguszewski, C. L., Bueno, C. B., Czepielewski, M. A., Portes, E. S., Nunes-Nogueira, V. S. [UNESP], Ribeiro-Oliveira, A., Francisco, R. P.V., Bronstein, M. D., Glezer, A.
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1007/s11102-019-01008-z; http://hdl.handle.net/11449/201082
• topic: Cabergoline; Dopamine agonist; Malformation; Miscarriage; Pregnancy; Prolactinoma

Objective: To evaluate the maternal–fetal outcomes of CAB-induced pregnancies in patients with prolactinoma in a large cohort. Methods: The prevalence of tumor growth, miscarriage, preterm, low birth weight, congenital malformations and impairment in neuropsychological development in children among women treated with CAB were assessed in a Brazilian multicentre retrospective observational study, Results: We included 194 women with a mean age of 31 (17–45) years, 43.6% presenting microadenomas and 56.4% macroadenomas, at prolactinoma diagnosis. In 233 pregnancies, CAB was withdrawn in 89%, after pregnancy confirmation. Symptoms related to tumor growth occurred in 25 cases, more frequently in macroadenomas. The overall miscarriage rate was 11%, although higher in the subgroup of patients with CAB maintainance after pregnancy confirmation (38% vs. 7.5%). Amongst the live-birth deliveries, preterm occurred in 12%, low birth weight in 6% and congenital malformations in 4.3%. Neuropsychological development impairment was reported in 7% of cases. Conclusions: Our findings confirm previous results of safety in maternal and fetal outcomes in CAB-induced pregnancies; nevertheless, CAB maintenance after pregnancy confirmation was associated with higher miscarriage rate; result that must be further confirmed.