Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

• Autor(a) principal: Francisqueti-Ferron, Fabiane Valentini [UNESP]
• Data de Publicação: 2019
• Outros Autores: Togneri Ferron, Artur Junio [UNESP], Garcia, Jessica Leite [UNESP], Vagula de Almeida Silva, Carol Cristina [UNESP], Costa, Mariane Rovero [UNESP], Gregolin, Cristina Schmitt [UNESP], Moreto, Fernando [UNESP], Ferreira, Ana Lucia A. [UNESP], Minatel, Igor Otavio [UNESP], Correa, Camila Renata [UNESP]
• Tipo de documento: Outros
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.3390/ijms20133208; http://hdl.handle.net/11449/184586
• topic: Nrf2; age-related disorders; oxidative stress

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.