Genetic polymorphisms on temporomandibular disorders: Network meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2025 |
Outros Autores: | , , , , , , |
Tipo de documento: | Outros |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.archoralbio.2025.106235 https://hdl.handle.net/11449/297811 |
Resumo: | Objective: The aim of this systematic review and network meta-analysis (NMA) is to compare and rank the effects of different genetic polymorphisms on the susceptibility of temporomandibular disorders (TMDs) occurrence. Design: The central question formulated was: “Are genetic polymorphisms involved in the etiology of TMDs?” Following PROSPERO registration (CRD42024507886), electronic searches were conducted in five databases for publications up to November 2024. Results: Sixty-three studies were included in the systematic review and 7 composed the NMA. The qualitative analysis summarized the association between 120 genes (and 206 polymorphisms) and TMDs. Thirty-two polymorphisms (in 24 genes) were linked to overall TMDs, while 22 polymorphisms (in 22 genes) with degenerative bone changes in the temporomandibular joint (TMJ). Additionally, 17 polymorphisms were identified in cases of painful chronic TMD, while 12 polymorphisms in intra-articular disorders. These polymorphisms were in genes related to neurotransmission (COMT, ADRB2, DRD2, ANKK1, SLC6A4 and HTR2A), inflammatory mediators (TNFα, IL10 and MMP1), sex hormones (ESR1and ESRRB), oxidative stress (GSTM1) and bone metabolism (VDR). A protective effect for myalgia occurrence with the COMT_rs165774 polymorphism compared to the wild-type genotype was found in the pairwise meta-analysis (AG genotype: OR: 0.33; 95 %CI: 0.14, 0.76; p < 0.01 and GG genotype: OR: 0.32; 95 %CI: 0.14, 0.74; p < 0.01) and this polymorphism showed the highest probability of being associated with the myalgia (97 %) and arthralgia (93 %) conditions. Conclusions: Genetic polymorphisms in genes related to neurotransmission, inflammatory response, and sex hormones seem to be risk factors related to the TMDs pathogenesis. |
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Genetic polymorphisms on temporomandibular disorders: Network meta-analysisPolymorphismSingle nucleotide polymorphismsTemporomandibular joint disordersObjective: The aim of this systematic review and network meta-analysis (NMA) is to compare and rank the effects of different genetic polymorphisms on the susceptibility of temporomandibular disorders (TMDs) occurrence. Design: The central question formulated was: “Are genetic polymorphisms involved in the etiology of TMDs?” Following PROSPERO registration (CRD42024507886), electronic searches were conducted in five databases for publications up to November 2024. Results: Sixty-three studies were included in the systematic review and 7 composed the NMA. The qualitative analysis summarized the association between 120 genes (and 206 polymorphisms) and TMDs. Thirty-two polymorphisms (in 24 genes) were linked to overall TMDs, while 22 polymorphisms (in 22 genes) with degenerative bone changes in the temporomandibular joint (TMJ). Additionally, 17 polymorphisms were identified in cases of painful chronic TMD, while 12 polymorphisms in intra-articular disorders. These polymorphisms were in genes related to neurotransmission (COMT, ADRB2, DRD2, ANKK1, SLC6A4 and HTR2A), inflammatory mediators (TNFα, IL10 and MMP1), sex hormones (ESR1and ESRRB), oxidative stress (GSTM1) and bone metabolism (VDR). A protective effect for myalgia occurrence with the COMT_rs165774 polymorphism compared to the wild-type genotype was found in the pairwise meta-analysis (AG genotype: OR: 0.33; 95 %CI: 0.14, 0.76; p < 0.01 and GG genotype: OR: 0.32; 95 %CI: 0.14, 0.74; p < 0.01) and this polymorphism showed the highest probability of being associated with the myalgia (97 %) and arthralgia (93 %) conditions. Conclusions: Genetic polymorphisms in genes related to neurotransmission, inflammatory response, and sex hormones seem to be risk factors related to the TMDs pathogenesis.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)School of Dentistry Alfenas Federal University (Unifal-MG), Minas GeraisDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State of University (FOAR/UNESP), São PauloDepartment of Periodontology and Implantodontology School of Dentistry Federal University of Uberlândia - UFU, Minas GeraisDepartment of Operative Dentistry and Dental Materials School of Dentistry Federal University of Uberlândia - UFU, Minas GeraisDepartment of Diagnosis and Surgery School of Dentistry at Araraquara São Paulo State of University (FOAR/UNESP), São PauloFAPEMIG: RED-0020423Alfenas Federal University (Unifal-MG)Universidade Estadual Paulista (UNESP)Universidade Federal de Uberlândia (UFU)Almeida, Daniel Augusto de FariaBrant, Camila Freireda Costa Siqueira, LetíciaSoares, Lélio Fernando Ferreira [UNESP]Oliveira, Jovânia Alvesde Oliveira, Daniela Silva BarrosoPigossi, Suzane CristinaSoares, Carlos José2025-04-29T18:07:47Z2025-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherhttp://dx.doi.org/10.1016/j.archoralbio.2025.106235Archives of Oral Biology, v. 174.1879-15060003-9969https://hdl.handle.net/11449/29781110.1016/j.archoralbio.2025.1062352-s2.0-105000141289Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArchives of Oral Biologyinfo:eu-repo/semantics/openAccess2025-05-01T06:00:05Zoai:repositorio.unesp.br:11449/297811Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-05-01T06:00:05Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
title |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
spellingShingle |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis Almeida, Daniel Augusto de Faria Polymorphism Single nucleotide polymorphisms Temporomandibular joint disorders |
title_short |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
title_full |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
title_fullStr |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
title_full_unstemmed |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
title_sort |
Genetic polymorphisms on temporomandibular disorders: Network meta-analysis |
author |
Almeida, Daniel Augusto de Faria |
author_facet |
Almeida, Daniel Augusto de Faria Brant, Camila Freire da Costa Siqueira, Letícia Soares, Lélio Fernando Ferreira [UNESP] Oliveira, Jovânia Alves de Oliveira, Daniela Silva Barroso Pigossi, Suzane Cristina Soares, Carlos José |
author_role |
author |
author2 |
Brant, Camila Freire da Costa Siqueira, Letícia Soares, Lélio Fernando Ferreira [UNESP] Oliveira, Jovânia Alves de Oliveira, Daniela Silva Barroso Pigossi, Suzane Cristina Soares, Carlos José |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Alfenas Federal University (Unifal-MG) Universidade Estadual Paulista (UNESP) Universidade Federal de Uberlândia (UFU) |
dc.contributor.author.fl_str_mv |
Almeida, Daniel Augusto de Faria Brant, Camila Freire da Costa Siqueira, Letícia Soares, Lélio Fernando Ferreira [UNESP] Oliveira, Jovânia Alves de Oliveira, Daniela Silva Barroso Pigossi, Suzane Cristina Soares, Carlos José |
dc.subject.por.fl_str_mv |
Polymorphism Single nucleotide polymorphisms Temporomandibular joint disorders |
topic |
Polymorphism Single nucleotide polymorphisms Temporomandibular joint disorders |
description |
Objective: The aim of this systematic review and network meta-analysis (NMA) is to compare and rank the effects of different genetic polymorphisms on the susceptibility of temporomandibular disorders (TMDs) occurrence. Design: The central question formulated was: “Are genetic polymorphisms involved in the etiology of TMDs?” Following PROSPERO registration (CRD42024507886), electronic searches were conducted in five databases for publications up to November 2024. Results: Sixty-three studies were included in the systematic review and 7 composed the NMA. The qualitative analysis summarized the association between 120 genes (and 206 polymorphisms) and TMDs. Thirty-two polymorphisms (in 24 genes) were linked to overall TMDs, while 22 polymorphisms (in 22 genes) with degenerative bone changes in the temporomandibular joint (TMJ). Additionally, 17 polymorphisms were identified in cases of painful chronic TMD, while 12 polymorphisms in intra-articular disorders. These polymorphisms were in genes related to neurotransmission (COMT, ADRB2, DRD2, ANKK1, SLC6A4 and HTR2A), inflammatory mediators (TNFα, IL10 and MMP1), sex hormones (ESR1and ESRRB), oxidative stress (GSTM1) and bone metabolism (VDR). A protective effect for myalgia occurrence with the COMT_rs165774 polymorphism compared to the wild-type genotype was found in the pairwise meta-analysis (AG genotype: OR: 0.33; 95 %CI: 0.14, 0.76; p < 0.01 and GG genotype: OR: 0.32; 95 %CI: 0.14, 0.74; p < 0.01) and this polymorphism showed the highest probability of being associated with the myalgia (97 %) and arthralgia (93 %) conditions. Conclusions: Genetic polymorphisms in genes related to neurotransmission, inflammatory response, and sex hormones seem to be risk factors related to the TMDs pathogenesis. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-04-29T18:07:47Z 2025-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/other |
format |
other |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.archoralbio.2025.106235 Archives of Oral Biology, v. 174. 1879-1506 0003-9969 https://hdl.handle.net/11449/297811 10.1016/j.archoralbio.2025.106235 2-s2.0-105000141289 |
url |
http://dx.doi.org/10.1016/j.archoralbio.2025.106235 https://hdl.handle.net/11449/297811 |
identifier_str_mv |
Archives of Oral Biology, v. 174. 1879-1506 0003-9969 10.1016/j.archoralbio.2025.106235 2-s2.0-105000141289 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Archives of Oral Biology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
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1834482406380273664 |