4-methylesculetin, a coumarin derivative, ameliorates dextran sulfate sodium-induced intestinal inflammation

• Main Author: Witaicenis, Aline [UNESP]
• Publication Date: 2018
• Other Authors: de Oliveira, Ellen Cristina Souza [UNESP], Tanimoto, Alexandre [UNESP], Zorzella-Pezavento, Sofia Fernanda Gonçalves [UNESP], de Oliveira, Silvio Luis [UNESP], Sartori, Alexandrina [UNESP], Di Stasi, Luiz Claudio [UNESP]
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1016/j.cbi.2017.12.006; http://hdl.handle.net/11449/175616
• topic: 4-methylesculetin; Antioxidant; Coumarin; DSS; Inflammatory bowel disease; Mice

4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities. Recent studies have shown that 4-methylesculetin has a promising potentiality to treat inflammatory diseases, especially those related to reactive oxygen species, as inflammatory bowel disease. Based on this, the present study aims to investigate the intestinal anti-inflammatory activity of 4-methylesculetin in dextran sulfate sodium (DSS) model. For this purpose, mice received DSS 5% for 5 days followed by 2 days of filtered tap water. Treated groups received orally 5 or 25 mg/kg of 4-methylesculetin daily since the first day. Macroscopic, microscopic and biochemical parameters were evaluated. 4-methylesculetin (25 mg/kg) improved microscopic parameters, decreased MPO activity, reduced the colonic levels of IL-6 and counteracted GSH depletion when compared with DSS-control group. Our results show the intestinal anti-inflammatory activity of 4-methylesculetin in DSS model, which is related to its antioxidant and anti-inflammatory properties. This way, 4-methylesculetin, is a new potential compound for treatment of both types of IBD.