Epigenetic regulatory mechanisms induced by resveratrol

Bibliographic Details
Main Author: Fernandes, Guilherme Felipe Santos [UNESP]
Publication Date: 2017
Other Authors: Silva, Gabriel Dalio Bernardes [UNESP], Pavan, Aline Renata [UNESP], Chiba, Diego Eidy [UNESP], Chin, Chung Man [UNESP], Dos Santos, Jean Leandro [UNESP]
Format: Other
Language: eng
Source: Repositório Institucional da UNESP
Download full: http://dx.doi.org/10.3390/nu9111201
http://hdl.handle.net/11449/179337
Summary: Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
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spelling Epigenetic regulatory mechanisms induced by resveratrolDNA methyltransferaseEpigenetic targetsHistone acetyltransferaseHistone deacetylaseResveratrolSIRT1Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)FAPESP: 2015/19531-1FAPESP: 2016/08470-4FAPESP: 2016/08880-8FAPESP: 2016/09502-7Universidade Estadual Paulista (Unesp)Fernandes, Guilherme Felipe Santos [UNESP]Silva, Gabriel Dalio Bernardes [UNESP]Pavan, Aline Renata [UNESP]Chiba, Diego Eidy [UNESP]Chin, Chung Man [UNESP]Dos Santos, Jean Leandro [UNESP]2018-12-11T17:34:45Z2018-12-11T17:34:45Z2017-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://dx.doi.org/10.3390/nu9111201Nutrients, v. 9, n. 11, 2017.2072-6643http://hdl.handle.net/11449/17933710.3390/nu91112012-s2.0-850334669192-s2.0-85033466919.pdf97343336079754130000-0003-4141-0455Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengNutrients1,557info:eu-repo/semantics/openAccess2025-03-29T05:20:14Zoai:repositorio.unesp.br:11449/179337Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-03-29T05:20:14Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Epigenetic regulatory mechanisms induced by resveratrol
title Epigenetic regulatory mechanisms induced by resveratrol
spellingShingle Epigenetic regulatory mechanisms induced by resveratrol
Fernandes, Guilherme Felipe Santos [UNESP]
DNA methyltransferase
Epigenetic targets
Histone acetyltransferase
Histone deacetylase
Resveratrol
SIRT1
title_short Epigenetic regulatory mechanisms induced by resveratrol
title_full Epigenetic regulatory mechanisms induced by resveratrol
title_fullStr Epigenetic regulatory mechanisms induced by resveratrol
title_full_unstemmed Epigenetic regulatory mechanisms induced by resveratrol
title_sort Epigenetic regulatory mechanisms induced by resveratrol
author Fernandes, Guilherme Felipe Santos [UNESP]
author_facet Fernandes, Guilherme Felipe Santos [UNESP]
Silva, Gabriel Dalio Bernardes [UNESP]
Pavan, Aline Renata [UNESP]
Chiba, Diego Eidy [UNESP]
Chin, Chung Man [UNESP]
Dos Santos, Jean Leandro [UNESP]
author_role author
author2 Silva, Gabriel Dalio Bernardes [UNESP]
Pavan, Aline Renata [UNESP]
Chiba, Diego Eidy [UNESP]
Chin, Chung Man [UNESP]
Dos Santos, Jean Leandro [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Fernandes, Guilherme Felipe Santos [UNESP]
Silva, Gabriel Dalio Bernardes [UNESP]
Pavan, Aline Renata [UNESP]
Chiba, Diego Eidy [UNESP]
Chin, Chung Man [UNESP]
Dos Santos, Jean Leandro [UNESP]
dc.subject.por.fl_str_mv DNA methyltransferase
Epigenetic targets
Histone acetyltransferase
Histone deacetylase
Resveratrol
SIRT1
topic DNA methyltransferase
Epigenetic targets
Histone acetyltransferase
Histone deacetylase
Resveratrol
SIRT1
description Resveratrol (RVT) is one of the main natural compounds studied worldwide due to its potential therapeutic use in the treatment of many diseases, including cancer, diabetes, cardiovascular diseases, neurodegenerative diseases and metabolic disorders. Nevertheless, the mechanism of action of RVT in all of these conditions is not completely understood, as it can modify not only biochemical pathways but also epigenetic mechanisms. In this paper, we analyze the biological activities exhibited by RVT with a focus on the epigenetic mechanisms, especially those related to DNA methyltransferase (DNMT), histone deacetylase (HDAC) and lysine-specific demethylase-1 (LSD1).
publishDate 2017
dc.date.none.fl_str_mv 2017-11-01
2018-12-11T17:34:45Z
2018-12-11T17:34:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.3390/nu9111201
Nutrients, v. 9, n. 11, 2017.
2072-6643
http://hdl.handle.net/11449/179337
10.3390/nu9111201
2-s2.0-85033466919
2-s2.0-85033466919.pdf
9734333607975413
0000-0003-4141-0455
url http://dx.doi.org/10.3390/nu9111201
http://hdl.handle.net/11449/179337
identifier_str_mv Nutrients, v. 9, n. 11, 2017.
2072-6643
10.3390/nu9111201
2-s2.0-85033466919
2-s2.0-85033466919.pdf
9734333607975413
0000-0003-4141-0455
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutrients
1,557
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1834482630328844288

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