A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny

Bibliographic Details
Main Author: Aldrovani, Marcela [UNESP]
Publication Date: 2017
Other Authors: Filezio, Marcella Rosa [UNESP], Laus, José Luiz [UNESP]
Format: Other
Language: eng
Source: Repositório Institucional da UNESP
Download full: http://dx.doi.org/10.5935/0004-2749.20170066
http://hdl.handle.net/11449/175193
Summary: Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.
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spelling A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progenyCellularCorneaCornealEpitheliumExtracellular matrixLimbus corneaeLiquid crystalMechanotransductionStem cell nicheVarious approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.Unidade de Oftalmologia Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (Unesp)Unidade de Oftalmologia Departamento de Clínica e Cirurgia Veterinária Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (Unesp)Universidade Estadual Paulista (Unesp)Aldrovani, Marcela [UNESP]Filezio, Marcella Rosa [UNESP]Laus, José Luiz [UNESP]2018-12-11T17:14:46Z2018-12-11T17:14:46Z2017-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/other268-272application/pdfhttp://dx.doi.org/10.5935/0004-2749.20170066Arquivos Brasileiros de Oftalmologia, v. 80, n. 4, p. 268-272, 2017.1678-29250004-2749http://hdl.handle.net/11449/17519310.5935/0004-2749.201700662-s2.0-850297199272-s2.0-85029719927.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros de Oftalmologia0,518info:eu-repo/semantics/openAccess2024-08-16T18:44:45Zoai:repositorio.unesp.br:11449/175193Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-08-16T18:44:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
spellingShingle A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
Aldrovani, Marcela [UNESP]
Cellular
Cornea
Corneal
Epithelium
Extracellular matrix
Limbus corneae
Liquid crystal
Mechanotransduction
Stem cell niche
title_short A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_full A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_fullStr A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_full_unstemmed A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
title_sort A supramolecular look at microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny
author Aldrovani, Marcela [UNESP]
author_facet Aldrovani, Marcela [UNESP]
Filezio, Marcella Rosa [UNESP]
Laus, José Luiz [UNESP]
author_role author
author2 Filezio, Marcella Rosa [UNESP]
Laus, José Luiz [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Aldrovani, Marcela [UNESP]
Filezio, Marcella Rosa [UNESP]
Laus, José Luiz [UNESP]
dc.subject.por.fl_str_mv Cellular
Cornea
Corneal
Epithelium
Extracellular matrix
Limbus corneae
Liquid crystal
Mechanotransduction
Stem cell niche
topic Cellular
Cornea
Corneal
Epithelium
Extracellular matrix
Limbus corneae
Liquid crystal
Mechanotransduction
Stem cell niche
description Various approaches have been taken to improve our knowledge of the microenvironmental regulation of limbal epithelial stem cells. Researchers have extensively investigated the roles of growth factors, survival factors, cytokines, enzymes, and permeable molecules secreted by the limbal cells. However, recent evidence suggests that stem cell fate (i.e., self-renewal or differentiation) can also be influenced by biophysical and mechanical cues related to the supramolecular organization and the liquid crystalline (mesophase) nature of the stromal extracellular matrix. These cues can be sensed by stem cells and transduced into intracellular biochemical and functional responses, a process known as mechanotransduction. The objective of this review is to offer perspectives on the supramolecular microenvironmental regulation of limbal epithelial stem cells and the differentiation of their progeny.
publishDate 2017
dc.date.none.fl_str_mv 2017-07-01
2018-12-11T17:14:46Z
2018-12-11T17:14:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/0004-2749.20170066
Arquivos Brasileiros de Oftalmologia, v. 80, n. 4, p. 268-272, 2017.
1678-2925
0004-2749
http://hdl.handle.net/11449/175193
10.5935/0004-2749.20170066
2-s2.0-85029719927
2-s2.0-85029719927.pdf
url http://dx.doi.org/10.5935/0004-2749.20170066
http://hdl.handle.net/11449/175193
identifier_str_mv Arquivos Brasileiros de Oftalmologia, v. 80, n. 4, p. 268-272, 2017.
1678-2925
0004-2749
10.5935/0004-2749.20170066
2-s2.0-85029719927
2-s2.0-85029719927.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
0,518
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 268-272
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1834483315436945408

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