Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?

Bibliographic Details
Main Author: Scorzoni, Liliana [UNESP]
Publication Date: 2018
Other Authors: De Paula E Silva, Ana Carolina Alves [UNESP], De Oliveira, Haroldo Cesar [UNESP], Marcos, Caroline Maria [UNESP], De Lacorte Singulani, Junya [UNESP], Fusco-Almeida, Ana Marisa [UNESP], Mendes-Giannini, Maria José Soares [UNESP]
Format: Article
Language: eng
Source: Repositório Institucional da UNESP
Download full: http://dx.doi.org/10.1093/mmy/myx045
http://hdl.handle.net/11449/176220
Summary: Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioidesspp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion.
id UNSP_2fc9bcabe70daf9b76f2a1d443b88c8d
oai_identifier_str oai:repositorio.unesp.br:11449/176220
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?AdhesinsFungal-host cell interactionGalleria mellonellaMiceParacoccidioides brasiliensisVirulence factorsParacoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioidesspp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú, Km 1Laboratório de Micologia Clínica Departamento de Análises Clínicas Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú, Km 1FAPESP: 2013/10917-9FAPESP: 2014/10446-9FAPESP: 2015/03700-9FAPESP: 2015/14023-8FAPESP: 2016/17048-4Universidade Estadual Paulista (Unesp)Scorzoni, Liliana [UNESP]De Paula E Silva, Ana Carolina Alves [UNESP]De Oliveira, Haroldo Cesar [UNESP]Marcos, Caroline Maria [UNESP]De Lacorte Singulani, Junya [UNESP]Fusco-Almeida, Ana Marisa [UNESP]Mendes-Giannini, Maria José Soares [UNESP]2018-12-11T17:19:40Z2018-12-11T17:19:40Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article374-377application/pdfhttp://dx.doi.org/10.1093/mmy/myx045Medical Mycology, v. 56, n. 3, p. 374-377, 2018.1460-27091369-3786http://hdl.handle.net/11449/17622010.1093/mmy/myx0452-s2.0-850459273232-s2.0-85045927323.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycology0,9730,973info:eu-repo/semantics/openAccess2025-03-29T05:11:58Zoai:repositorio.unesp.br:11449/176220Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462025-03-29T05:11:58Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
title Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
spellingShingle Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
Scorzoni, Liliana [UNESP]
Adhesins
Fungal-host cell interaction
Galleria mellonella
Mice
Paracoccidioides brasiliensis
Virulence factors
title_short Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
title_full Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
title_fullStr Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
title_full_unstemmed Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
title_sort Can passage in Galleria mellonella activate virulence factors of Paracoccidioides brasiliensis as in the murine model?
author Scorzoni, Liliana [UNESP]
author_facet Scorzoni, Liliana [UNESP]
De Paula E Silva, Ana Carolina Alves [UNESP]
De Oliveira, Haroldo Cesar [UNESP]
Marcos, Caroline Maria [UNESP]
De Lacorte Singulani, Junya [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
author_role author
author2 De Paula E Silva, Ana Carolina Alves [UNESP]
De Oliveira, Haroldo Cesar [UNESP]
Marcos, Caroline Maria [UNESP]
De Lacorte Singulani, Junya [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Scorzoni, Liliana [UNESP]
De Paula E Silva, Ana Carolina Alves [UNESP]
De Oliveira, Haroldo Cesar [UNESP]
Marcos, Caroline Maria [UNESP]
De Lacorte Singulani, Junya [UNESP]
Fusco-Almeida, Ana Marisa [UNESP]
Mendes-Giannini, Maria José Soares [UNESP]
dc.subject.por.fl_str_mv Adhesins
Fungal-host cell interaction
Galleria mellonella
Mice
Paracoccidioides brasiliensis
Virulence factors
topic Adhesins
Fungal-host cell interaction
Galleria mellonella
Mice
Paracoccidioides brasiliensis
Virulence factors
description Paracoccidioidomycosis (PCM) is a fungal disease restricted to Latin countries, and its etiologic agents derive from the Paracoccidioides genus. Attenuation or loss of virulence in Paracoccidioidesspp. following successive subculturing has been described. However, virulence can be recovered by passage in mammalian host. In this study, the recovery of adhesion of P. brasiliensis through passage in mice was compared to that in the insect Galleria mellonella. Analysis of in vitro fungal-host cell interaction, gene expression of adhesins, and analysis of the survival curves revealed that Galleria mellonella is useful for the reactivation of P. brasiliensis adhesion.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-11T17:19:40Z
2018-12-11T17:19:40Z
2018-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/mmy/myx045
Medical Mycology, v. 56, n. 3, p. 374-377, 2018.
1460-2709
1369-3786
http://hdl.handle.net/11449/176220
10.1093/mmy/myx045
2-s2.0-85045927323
2-s2.0-85045927323.pdf
url http://dx.doi.org/10.1093/mmy/myx045
http://hdl.handle.net/11449/176220
identifier_str_mv Medical Mycology, v. 56, n. 3, p. 374-377, 2018.
1460-2709
1369-3786
10.1093/mmy/myx045
2-s2.0-85045927323
2-s2.0-85045927323.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical Mycology
0,973
0,973
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 374-377
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1834482788834738176

Similar Items