Euterpe oleracea mart. (açaí) reduces oxidative stress and improves energetic metabolism in myocardial ischemia-reperfusion injury in rats

• Autor(a) principal: Alegre, Patricia [UNESP]
• Data de Publicação: 2020
• Outros Autores: Mathias, Livia [UNESP], Lourenço, Maria Angelica [UNESP], Dos Santos, Priscila Portugal [UNESP], Gonçalves, Andrea [UNESP], Fernandes, Ana Angélica [UNESP], Gaiolla, Paula Schmidt Azevedo [UNESP], Minicucci, Marcos Ferreira [UNESP], Zornoff, Leonardo [UNESP], Paiva, Sergio Alberto Rupp [UNESP], Polegato, Bertha Furlan [UNESP]
• Tipo de documento: Artigo
• Idioma: eng; por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.36660/abc.20180140; http://hdl.handle.net/11449/201552
• topic: Chemical Reactions; Energy Metabolism; Euterpe Olerácea; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidative Stress; Rats

Background: Euterpe oleracea Mart. (açaí) is a fruit with high antioxidant capacity and could be an adjuvant strategy to attenuate ischemia-reperfusion injury. Objective: To evaluate the influence of açaí in global ischemia-reperfusion model in rats. Methods: Wistar rats were assigned to 2 groups: Control (C: receiving standard chow; n = 9) and Açaí (A: receiving standard chow supplemented with 5% açaí; n = 10). After six weeks, the animals were subjected to the global ischemia-reperfusion protocol and an isolated heart study to evaluate left ventricular function. Level of significance adopted: 5%. Results: There was no difference between the groups in initial body weight, final body weight and daily feed intake. Group A presented lower lipid hydroperoxide myocardial concentration and higher catalase activity, superoxide dismutase and glutathione peroxidase than group C. We also observed increased myocardial activity of β-hydroxyacyl coenzyme-A dehydrogenase, pyruvate dehydrogenase, citrate synthase, complex I, complex II and ATP synthase in the A group as well as lower activity of the lactate dehydrogenase and phosphofructokinase enzymes. The systolic function was similar between the groups, and the A group presented poorer diastolic function than the C group. We did not observe any difference between the groups in relation to myocardial infarction area, total and phosphorylated NF-κB, total and acetylated FOXO1, SIRT1 and Nrf-2 protein expression. Conclusion: despite improving energy metabolism and attenuating oxidative stress, açai supplementation did not decrease the infarcted area or improve left ventricular function in the global ischemia-reperfusion model. (Arq Bras Cardiol. 2020; 114(1):78-86).