Determination of 5-aminosalicylic acid in pharmaceutical formulations by square wave voltammetry at pencil graphite electrodes

• Main Author: Uliana, Carolina V. [UNESP]
• Publication Date: 2010
• Other Authors: Yamanaka, Hideko [UNESP], Garbellini, Gustavo S., Salazar-Banda, Giancarlo R.
• Format: Article
• Language: eng
• Source: Repositório Institucional da UNESP
• Download full: http://dx.doi.org/10.1590/S0100-40422010000400036; http://hdl.handle.net/11449/25697
• topic: 5-aminosalicylic acid; pharmaceutical formulations; pencil graphite electrode

An analytical method for the determination of the anti-inflammatory drug 5-aminosalicylic acid (5-ASA) in pharmaceutical formulations using square wave voltammetry at pencil graphite electrodes was developed. After the optimization of the experimental conditions, calibration curves were obtained in the linear concentration range from 9.78 × 10-7 to 7.25 × 10-5 mol L-1 resulting in a limit of detection of 2.12 ± 0.05 x 10-8 mol L-1. Statistical tests showed that the concentrations of 5-ASA in commercial tablets and enemas obtained with the proposed voltammetric method agreed with HPLC values at a 95% confidence level.