Inhibitors of Clostridium histolyticum colagenase

Bibliographic Details
Main Author: Leite,S. R. A.
Publication Date: 2008
Format: Article
Language: eng
Source: Eclética Química
Download full: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400006
Summary: Different substances were tested as inhibitors of Clostridium histolyticum collagenase, both experimental and theoretically. The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by reaction with bovine collagen and dosage of the releasing amino acids. Collagenase-inhibitor interaction was studied theoretically by docking computational calculations. Only one among the tested substances showed inhibitor activity against the bacterial collagenase.
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spelling Inhibitors of Clostridium histolyticum colagenaseClostridium histolyticumcollagenaseinhibitorsdockingDifferent substances were tested as inhibitors of Clostridium histolyticum collagenase, both experimental and theoretically. The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by reaction with bovine collagen and dosage of the releasing amino acids. Collagenase-inhibitor interaction was studied theoretically by docking computational calculations. Only one among the tested substances showed inhibitor activity against the bacterial collagenase.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400006Eclética Química v.33 n.4 2008reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702008000400006info:eu-repo/semantics/openAccessLeite,S. R. A.eng2009-01-12T00:00:00Zoai:scielo:S0100-46702008000400006Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2009-01-12T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false
dc.title.none.fl_str_mv Inhibitors of Clostridium histolyticum colagenase
title Inhibitors of Clostridium histolyticum colagenase
spellingShingle Inhibitors of Clostridium histolyticum colagenase
Leite,S. R. A.
Clostridium histolyticum
collagenase
inhibitors
docking
title_short Inhibitors of Clostridium histolyticum colagenase
title_full Inhibitors of Clostridium histolyticum colagenase
title_fullStr Inhibitors of Clostridium histolyticum colagenase
title_full_unstemmed Inhibitors of Clostridium histolyticum colagenase
title_sort Inhibitors of Clostridium histolyticum colagenase
author Leite,S. R. A.
author_facet Leite,S. R. A.
author_role author
dc.contributor.author.fl_str_mv Leite,S. R. A.
dc.subject.por.fl_str_mv Clostridium histolyticum
collagenase
inhibitors
docking
topic Clostridium histolyticum
collagenase
inhibitors
docking
description Different substances were tested as inhibitors of Clostridium histolyticum collagenase, both experimental and theoretically. The in vitro collagenase activity, alone and in the presence of inhibitors, was quantified by reaction with bovine collagen and dosage of the releasing amino acids. Collagenase-inhibitor interaction was studied theoretically by docking computational calculations. Only one among the tested substances showed inhibitor activity against the bacterial collagenase.
publishDate 2008
dc.date.none.fl_str_mv 2008-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-46702008000400006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
publisher.none.fl_str_mv Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP
dc.source.none.fl_str_mv Eclética Química v.33 n.4 2008
reponame:Eclética Química
instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Eclética Química
collection Eclética Química
repository.name.fl_str_mv Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
repository.mail.fl_str_mv ecletica@ctrlk.com.br||ecletica@iq.unesp.br
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