Kleine-Levin syndrome: interface between neurology and psychiatry

Bibliographic Details
Main Author: Justo, Luís Pereira [UNIFESP]
Publication Date: 2007
Other Authors: Calil, Helena Maria [UNIFESP], Bolognani, Silvia Adriana Prado [UNIFESP], Muszkat, Mauro [UNIFESP]
Format: Article
Language: eng
Source: Repositório Institucional da UNIFESP
Download full: https://dx.doi.org/10.1590/S0004-282X2007000100030
https://repositorio.unifesp.br/handle/11600/3593
Summary: We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysonographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepness control and to the best of our knowledge there are no other report regarding risperidone use for KLS in the literature.
id UFSP_fe47de47a2bea7b6efcf79be19a36698
oai_identifier_str oai:repositorio.unifesp.br/:11600/3593
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Kleine-Levin syndrome: interface between neurology and psychiatrySíndrome de Kleine-Levin: interface entre neurologia e psiquiatriaKleine-LevinNeuropsychologyPolysomnographyRisperidoneSleep disordersKleine-LevinNeuropsicologiaPolissonografiaRisperidonaTranstorno de sonoWe report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysonographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepness control and to the best of our knowledge there are no other report regarding risperidone use for KLS in the literature.Relatamos o primeiro episódio de síndrome de Kleine-Levin (SKL) num adolescente de 17 anos. São descritos o modo de aparecimento da doença, achados clínicos, avaliação neuropsicológica e polissonografia. Foram observados sintomas típicos como hipersonolência, hiperfagia e desinibição sexual, e outras alterações comportamentais, polissonográficas e neuropsicológicas. As alterações comportamentais assemelhadas a um episódio de mania, incluindo sintomas psicóticos, foram relevantes. O tratamento farmacológico incluiu lítio, metilfenidato e risperidona. A introdução de risperidona teve por objetivo o controle dos sintomas psicóticos e das persistentes manifestações da hipersexualidade, que permaneceram após diminuição da sonolência; não temos conhecimento de relatos anteriores, na literatura, de seu uso no tratamento da SKL.Federal University of São Paulo Department of PychobilogyUNIFESP, Department of PychobilogySciELOAcademia Brasileira de Neurologia - ABNEUROUniversidade Federal de São Paulo (UNIFESP)Justo, Luís Pereira [UNIFESP]Calil, Helena Maria [UNIFESP]Bolognani, Silvia Adriana Prado [UNIFESP]Muszkat, Mauro [UNIFESP]2015-06-14T13:36:47Z2015-06-14T13:36:47Z2007-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion150-152application/pdfhttps://dx.doi.org/10.1590/S0004-282X2007000100030Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 65, n. 1, p. 150-152, 2007.10.1590/S0004-282X2007000100030S0004-282X2007000100030.pdf0004-282XS0004-282X2007000100030https://repositorio.unifesp.br/handle/11600/3593engArquivos de Neuro-Psiquiatriainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T12:51:08Zoai:repositorio.unifesp.br/:11600/3593Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T12:51:08Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Kleine-Levin syndrome: interface between neurology and psychiatry
Síndrome de Kleine-Levin: interface entre neurologia e psiquiatria
title Kleine-Levin syndrome: interface between neurology and psychiatry
spellingShingle Kleine-Levin syndrome: interface between neurology and psychiatry
Justo, Luís Pereira [UNIFESP]
Kleine-Levin
Neuropsychology
Polysomnography
Risperidone
Sleep disorders
Kleine-Levin
Neuropsicologia
Polissonografia
Risperidona
Transtorno de sono
title_short Kleine-Levin syndrome: interface between neurology and psychiatry
title_full Kleine-Levin syndrome: interface between neurology and psychiatry
title_fullStr Kleine-Levin syndrome: interface between neurology and psychiatry
title_full_unstemmed Kleine-Levin syndrome: interface between neurology and psychiatry
title_sort Kleine-Levin syndrome: interface between neurology and psychiatry
author Justo, Luís Pereira [UNIFESP]
author_facet Justo, Luís Pereira [UNIFESP]
Calil, Helena Maria [UNIFESP]
Bolognani, Silvia Adriana Prado [UNIFESP]
Muszkat, Mauro [UNIFESP]
author_role author
author2 Calil, Helena Maria [UNIFESP]
Bolognani, Silvia Adriana Prado [UNIFESP]
Muszkat, Mauro [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Justo, Luís Pereira [UNIFESP]
Calil, Helena Maria [UNIFESP]
Bolognani, Silvia Adriana Prado [UNIFESP]
Muszkat, Mauro [UNIFESP]
dc.subject.por.fl_str_mv Kleine-Levin
Neuropsychology
Polysomnography
Risperidone
Sleep disorders
Kleine-Levin
Neuropsicologia
Polissonografia
Risperidona
Transtorno de sono
topic Kleine-Levin
Neuropsychology
Polysomnography
Risperidone
Sleep disorders
Kleine-Levin
Neuropsicologia
Polissonografia
Risperidona
Transtorno de sono
description We report the first episode of Kleine-Levin (KLS) syndrome in a 17-year-old male. The illness onset, clinical features, neuropsychological evaluation and polysomnographic recording are described. Typical symptoms hypersomnia, hyperphagia and sexual disinhibition were observed besides behavioral disturbances, polysonographic and neuropsychological alterations. Behavioral disturbances similar to a manic episode including psychotic symptoms were relevant. The pharmacologic treatment included lithium, methylphenidate and risperidone. The introduction of risperidone aimed the control of psychotic symptoms and the persistent manifestations of hypersexuality after sleepness control and to the best of our knowledge there are no other report regarding risperidone use for KLS in the literature.
publishDate 2007
dc.date.none.fl_str_mv 2007-03-01
2015-06-14T13:36:47Z
2015-06-14T13:36:47Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://dx.doi.org/10.1590/S0004-282X2007000100030
Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 65, n. 1, p. 150-152, 2007.
10.1590/S0004-282X2007000100030
S0004-282X2007000100030.pdf
0004-282X
S0004-282X2007000100030
https://repositorio.unifesp.br/handle/11600/3593
url https://dx.doi.org/10.1590/S0004-282X2007000100030
https://repositorio.unifesp.br/handle/11600/3593
identifier_str_mv Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 65, n. 1, p. 150-152, 2007.
10.1590/S0004-282X2007000100030
S0004-282X2007000100030.pdf
0004-282X
S0004-282X2007000100030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos de Neuro-Psiquiatria
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 150-152
application/pdf
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
publisher.none.fl_str_mv Academia Brasileira de Neurologia - ABNEURO
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1841453482410770432

Similar Items