Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
| Main Author: | |
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| Publication Date: | 2017 |
| Other Authors: | , , , , , , |
| Format: | Article |
| Language: | eng |
| Source: | Repositório Institucional da UNIFESP |
| Download full: | http://dx.doi.org/10.1590/s0102-865020170090000005 http://repositorio.unifesp.br/handle/11600/51254 |
Summary: | Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate |
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Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in miceWound HealingAngiogenesis Modulating AgentsAnti-Inflammatory AgentsPhytotherapySkinMicePurpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure ratethe inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-beta-D-glucosaminidase activities. The levels of TNF-alpha, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.Univ Fed Rural Pernambuco UFRPE, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilUniv Fed Rural Pernambuco, Dept Chem, Recife, PE, BrazilUniv Fed Rural Pernambuco, Dept Morphol & Anim Physiol, Recife, PE, BrazilUniv Fed São Paulo UNIFESP, Dept Morphol & Genet, São Paulo, BrazilWeb of ScienceFundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Acta Cirurgica Brasileira2019-08-19T11:48:27Z2019-08-19T11:48:27Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion726-735application/pdfhttp://dx.doi.org/10.1590/s0102-865020170090000005Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017.10.1590/s0102-865020170090000005WOS000412738500005.pdf0102-8650S0102-86502017000900726http://repositorio.unifesp.br/handle/11600/51254WOS:000412738500005enginfo:eu-repo/semantics/openAccessMoura Estevao, Ligia ReisSimoes, Ricardo Santos [UNIFESP]Cassini-Vieira, PueblaCampos Canesso, Maria CeciliaBarcelos, Luciola da SilvaRachid, Milene AlvarengaGomes da Cmara, Claudio AugustoEvencio-Neto, Joaquimreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-10T20:40:59Zoai:repositorio.unifesp.br/:11600/51254Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-10T20:40:59Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| title |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| spellingShingle |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice Moura Estevao, Ligia Reis Wound Healing Angiogenesis Modulating Agents Anti-Inflammatory Agents Phytotherapy Skin Mice |
| title_short |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| title_full |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| title_fullStr |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| title_full_unstemmed |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| title_sort |
Schinus terebinthifolius Raddi (Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice |
| author |
Moura Estevao, Ligia Reis |
| author_facet |
Moura Estevao, Ligia Reis Simoes, Ricardo Santos [UNIFESP] Cassini-Vieira, Puebla Campos Canesso, Maria Cecilia Barcelos, Luciola da Silva Rachid, Milene Alvarenga Gomes da Cmara, Claudio Augusto Evencio-Neto, Joaquim |
| author_role |
author |
| author2 |
Simoes, Ricardo Santos [UNIFESP] Cassini-Vieira, Puebla Campos Canesso, Maria Cecilia Barcelos, Luciola da Silva Rachid, Milene Alvarenga Gomes da Cmara, Claudio Augusto Evencio-Neto, Joaquim |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Moura Estevao, Ligia Reis Simoes, Ricardo Santos [UNIFESP] Cassini-Vieira, Puebla Campos Canesso, Maria Cecilia Barcelos, Luciola da Silva Rachid, Milene Alvarenga Gomes da Cmara, Claudio Augusto Evencio-Neto, Joaquim |
| dc.subject.por.fl_str_mv |
Wound Healing Angiogenesis Modulating Agents Anti-Inflammatory Agents Phytotherapy Skin Mice |
| topic |
Wound Healing Angiogenesis Modulating Agents Anti-Inflammatory Agents Phytotherapy Skin Mice |
| description |
Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO-treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2019-08-19T11:48:27Z 2019-08-19T11:48:27Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s0102-865020170090000005 Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017. 10.1590/s0102-865020170090000005 WOS000412738500005.pdf 0102-8650 S0102-86502017000900726 http://repositorio.unifesp.br/handle/11600/51254 WOS:000412738500005 |
| url |
http://dx.doi.org/10.1590/s0102-865020170090000005 http://repositorio.unifesp.br/handle/11600/51254 |
| identifier_str_mv |
Acta Cirurgica Brasileira. Sao Paulo, v. 32, n. 9, p. 726-735, 2017. 10.1590/s0102-865020170090000005 WOS000412738500005.pdf 0102-8650 S0102-86502017000900726 WOS:000412738500005 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
726-735 application/pdf |
| dc.publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
| publisher.none.fl_str_mv |
Acta Cirurgica Brasileira |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1841453539318038528 |